| 基于邻香草醛缩2-氨基-4-硝基苯酚的Schiff碱有机锡配合物的合成、晶体结构及生物活性 |
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| 引用本文： | 蒋伍玖,伍徐孟,刘超,庾江喜,朱小明,冯泳兰,张复兴,邝代治.基于邻香草醛缩2-氨基-4-硝基苯酚的Schiff碱有机锡配合物的合成、晶体结构及生物活性[J].无机化学学报,2015,31(7):1321-1328. |
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| 作者姓名： | 蒋伍玖 伍徐孟 刘超 庾江喜 朱小明 冯泳兰 张复兴 邝代治 |
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| 作者单位： | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,湘南学院化学与生命科学系, 郴州 423043,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008,功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 |
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| 基金项目： | 湖南省科技计划项目(No.2013TZ2025, 2014NK3086, 2014FJ3060)和自然科学基金(No.13JJ3112), 湖南省普通高校重点实验室开放基金 项目(No.13K105, 14K014), 湖南省教育厅基金项目(No.14C0171), 功能金属有机材料湖南省普通高校重点实验室开放基金项目 (No.13K01, 13K04, GN14K01)资助。 |
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| 摘 要： | 邻香草醛缩2-氨基4-硝基苯酚(H2L)分别与二丁基氧化锡、二苄基二氯化锡反应, 合成了二丁基锡Schiff碱配合物(1)和单苄基Schiff碱配合物(2)。配合物经元素分析、1H NMR、13C NMR、IR、UV-Vis表征, 并用X-射线单晶衍射测定了分子结构。研究了配体H2L及配合物1、2对癌细胞Hela、MCF7、HepG2、Colo205、NCI-H460的抑制活性, 结果表明配合物1对这5种癌细胞的抑制效果优于现有抗癌药物卡铂, 可作为抗癌药物的候选化合物。在Tris缓冲溶液中, 以EB做为荧光探针, 用荧光光谱法研究了配体H2L及配合物2与鲱鱼精DNA的相互作用, 结果表明配合物与DNA作用主要是由于Schiff碱配体协同效应所致。
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| 关 键 词： | 有机锡 Schiff碱 晶体结构 生物活性 |
| 收稿时间： | 2014/12/28 0:00:00 |
| 修稿时间： | 2015/1/26 0:00:00 |
Syntheses, Crystal Structures and Biological Activity of Schiff Base Organotin Complexes Based on o-Vanillin and 2-Amino-4-nitrophenol |
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| JIANG Wu-Jiu,WU Xu-Meng,LIU Chao,YU Jiang-Xi,ZHU Xiao-Ming,FENG Yong-Lan,ZHANG Fu-Xing and KUANG Dai-Zhi.Syntheses, Crystal Structures and Biological Activity of Schiff Base Organotin Complexes Based on o-Vanillin and 2-Amino-4-nitrophenol[J].Chinese Journal of Inorganic Chemistry,2015,31(7):1321-1328. |
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| Authors: | JIANG Wu-Jiu WU Xu-Meng LIU Chao YU Jiang-Xi ZHU Xiao-Ming FENG Yong-Lan ZHANG Fu-Xing and KUANG Dai-Zhi |
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| Institution: | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Department of Chemistry and Life Science, Xiangnan University, Chenzhou, Hunan 423043, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China and Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Schiff base organotin complexes 1 and 2 have been synthesized via the reaction of the o-Vanillin-2-amino-4-nitrophenol Schiff base(H2L) with the dibutyltin oxide and the dibenzyltin dichloride, respectively. The complexes have been characterized by IR, 1H NMR, 13C NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. The anticancer activity of H2L, 1 and 2 against five species of cancer cell which are Hela, MCF7, HepG2, Colo205, NCI-H460 were tested respectively, and the tests showed that complex 1 was more active than carboplatin against tested carcinoma cell lines and has a potential application of drug preparation. The interaction between Schiff base ligand, complex 2 and Herring sperm DNA were studied by EB fluorescent probe, the result shows that fluorescence quenching was really resulted from the synergistic effect of the Schiff base ligand. CCDC: 939077, 1; 939078, 2. |
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| Keywords: | organotin Schiff base crystal structure biological activity |
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