| 磺酸基邻苯二甲酰亚氨甲基酞菁锌的合成及光动力抗肿瘤活性研究 |
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| 引用本文： | 刘尔生,黄剑东,戴志飞,杨素苓,吴谊群,陈耐生,黄金陵,黄自强,孙建成,许建华.磺酸基邻苯二甲酰亚氨甲基酞菁锌的合成及光动力抗肿瘤活性研究[J].无机化学学报,1997,13(4):411-415. |
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| 作者姓名： | 刘尔生 黄剑东 戴志飞 杨素苓 吴谊群 陈耐生 黄金陵 黄自强 孙建成 许建华 |
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| 作者单位： | 福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福州大学化学系，福州大学功能材料研究所， 福州350002,福建医科大学肿瘤药理研究室， 福州 350004,福建医科大学肿瘤药理研究室， 福州 350004,福建医科大学肿瘤药理研究室， 福州 350004 |
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| 基金项目： | 福建省科委资助,厦门大学固体表面物理化学国家重点实验室部分资助项目 |
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| 摘 要： | 合成了含不同数目磺酸基(以S表示)和邻苯二甲酰亚氨甲基(以P表示)的酞菁锌配合物的混合物，采用反相高效液相色谱进行分离，得到的D组分，经元素分析其组成为ZnPcS2P2两亲性配合物，对该配合物进行了IR、UV/Vis光谱表征，并研究了其在体对S180和U14实体瘤的光动力活性和机理。
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| 关 键 词： | 两亲性酞菁锌 合成 光动力活性 抗肿瘤机理 |
STUDIES ON THE SYNTHESIS AND PHOTODYNAMIC ANTITUMOUR ACTIVITY OF SULFONATED PHTHALIMIDOMETHYL PHTHALOCYANINE ZINC |
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| Liu Ersheng,Huang Jiandong,Dai Zhifei,Yang Suling,Wu Yiqun,Chen Naisheng,Huang Jinling,Huang Ziqiang,Sun Jiangcheng and Xu Jianhua.STUDIES ON THE SYNTHESIS AND PHOTODYNAMIC ANTITUMOUR ACTIVITY OF SULFONATED PHTHALIMIDOMETHYL PHTHALOCYANINE ZINC[J].Chinese Journal of Inorganic Chemistry,1997,13(4):411-415. |
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| Authors: | Liu Ersheng Huang Jiandong Dai Zhifei Yang Suling Wu Yiqun Chen Naisheng Huang Jinling Huang Ziqiang Sun Jiangcheng and Xu Jianhua |
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| Institution: | Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002,Cancer Pharmacology Research Section, Fujian Medical University, Fuzhou 350004,Cancer Pharmacology Research Section, Fujian Medical University, Fuzhou 350004 and Cancer Pharmacology Research Section, Fujian Medical University, Fuzhou 350004 |
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| Abstract: | Zinc phthalocyanines subsituted to different degrees with hydrophilic sulfphonic acid and hydrophobic phthalimidomethyl groups were synthesized and separated on a semi-preparative reverse phase HPLC column packed with ODS(C-18) spherisob. The ZnPcS2P2 was obtianed and characterized by elemental analyses, IR spectra and UV/Vis spectra. The photodynamic therapy effects of ZnPcS2P2 in vivo showed that growth of S180 and U14 solid carcinoma was inhibited significantly. The inhibitory rate was 76.7% and 68.7% respectively. Its antineoplastic mechanism by PDT was also researched preliminarily. |
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| Keywords: | hydrophilic-lipophilic zinc phthalocyanine synthesis photodynamic activity antineoplastic mechanism |
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