| 硒酸酯多糖抗石英细胞毒性的研究 |
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| 引用本文： | 刘永民,王金晞,朱卫华,魏金华,陈荣三.硒酸酯多糖抗石英细胞毒性的研究[J].无机化学学报,1995,11(1):24-28. |
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| 作者姓名： | 刘永民 王金晞 朱卫华 魏金华 陈荣三 |
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| 作者单位： | 南京大学配位化学研究所，南京配位化学国家重点实验室，徐州医学院 |
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| 摘 要： | 本文采用家兔肺泡巨噬细胞体外培养法，以ＡＲ－ＣＭ阳离子测定系统和荧光试剂Ｆｕｒａ－２，研究了石英细胞毒性与肺泡巨噬细胞胞胞浆游离Ｃａ＾２＋浓度（［Ｃａ＾２＋］ｉ）的关系，并以细胞存活率，乳酸脱氢酶活性和脂质过氧化物表征了由石英引起的ＡＭ毒性及硒酸酯多糖对其毒性的拮抗效应，初步讨论了硒酸酯多糖拮抗石英细胞毒性的可能机理。
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| 关 键 词： | 硒酸酯多糖 石英 细胞毒性 LDH LPO AM 钙 矽肺 |
| 收稿时间： | 1994/1/25 0:00:00 |
RESEARCH OF ANTAGONISM OF KAPPASELENOCARRAGEENAN TO CYTOTOXITY OF QUARTZ |
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| Liu Yongmin,Wang Jinxi,Zhu Weihu,Wei Jinhua and Chen Rongsan.RESEARCH OF ANTAGONISM OF KAPPASELENOCARRAGEENAN TO CYTOTOXITY OF QUARTZ[J].Chinese Journal of Inorganic Chemistry,1995,11(1):24-28. |
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| Authors: | Liu Yongmin Wang Jinxi Zhu Weihu Wei Jinhua and Chen Rongsan |
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| Institution: | Institute of Coordination Chemistry.State Key Laboratory of Coordination Chemistry. Nanjing University. Nanjing 210093 |
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| Abstract: | In this article, the relation between the eytotoxicity of quartz and the change of cytoplasmic free Ca(2 ) of alveolar macrophage was studied by means of AR-CM cation measurement system and fluorescence solvent Fura-2. Both the cytotoxicity of quartz and the antagonized effects of Kappa-selenocarrageenan were characterized by the survival percent of cells, the activities of LDH and LPO as well. In addition, the mechanism of Kappa-selenocarragcenan's suppressing cytotoxicity of quartz was also disscussed. |
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| Keywords: | Kappa-selenocarrageenan quartz cytotoxicity cytoplasmic free Ca2+ |
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