| pH值和金属离子对尖吻蝮蛇抗凝血因子Ⅱ二级结构的影响 |
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| 引用本文： | 陈结霞,徐小龙,刘祥虎,刘清亮.pH值和金属离子对尖吻蝮蛇抗凝血因子Ⅱ二级结构的影响[J].无机化学学报,2006,22(1):69-72. |
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| 作者姓名： | 陈结霞 徐小龙 刘祥虎 刘清亮 |
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| 作者单位： | 中国科学技术大学化学系,合肥,230026 |
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| 摘 要： | 圆二色谱(CD谱)测量表明，尖吻蝮蛇抗凝血因子Ⅱ(ACF Ⅱ)与抗凝血因子Ⅰ(ACF Ⅰ)的二级结构十分相似，它们的主要骨架构象都为反平行β-折叠和α-螺旋结构。pH值对天然ACF Ⅱ的构象有一定的影响，pH值从3到10增大时，α-螺旋含量逐渐减少，反平行β-折叠含量逐渐增大。钙和其他二价金属离子对ACF Ⅱ的骨架结构没有明显影响。三价稀土离子使ACF Ⅱ的α-螺旋含量升高，同时降低其β-转角和β-折叠的含量。
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| 关 键 词： | 抗凝血因子Ⅱ 酸度(pH) 二级结构 圆二色谱 |
| 文章编号： | 1001-4861(2006)01-0069-04 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2005-09-08 |
The Effects of pH and Metal Ions on the Secondary Structure of Anticogulation Factor Ⅱ Studed by CD Spectroscopy |
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| CHEN Jie-Xi,XU Xiao-Long,LIU Xiang-Hu and LIU Qing-Liang.The Effects of pH and Metal Ions on the Secondary Structure of Anticogulation Factor Ⅱ Studed by CD Spectroscopy[J].Chinese Journal of Inorganic Chemistry,2006,22(1):69-72. |
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| Authors: | CHEN Jie-Xi XU Xiao-Long LIU Xiang-Hu and LIU Qing-Liang |
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| Institution: | Department of Chemistry, University of Science and Technology of China, Hefei 230026,Department of Chemistry, University of Science and Technology of China, Hefei 230026,Department of Chemistry, University of Science and Technology of China, Hefei 230026 and Department of Chemistry, University of Science and Technology of China, Hefei 230026 |
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