|
|||||
|
|
| 新型三元铜配合物的合成、晶体结构及与DNA的相互作用 | |
| 引用本文： | 周建良,春晓改,周琳姣,陈 云,张寿春.新型三元铜配合物的合成、晶体结构及与DNA的相互作用[J].无机化学学报,2010,26(4):645-650. |
| 作者姓名： | 周建良 春晓改 周琳姣 陈 云 张寿春 |
| 作者单位： | 1. 中南大学化学化工学院,长沙,410083 2. 南京大学配位化学国家重点实验室,南京,210093 3. 湖南大学化学化工学院,长沙,410082 4. 中南大学化学化工学院,长沙,410083;南京大学配位化学国家重点实验室,南京,210093 |
| 基金项目： | 中南大学人才引进基金，南京大学配位化学国家重点实验室开放基金资助 |
| 摘 要： | 合成了一种新型的三元铜配合物Cu(Dppz)(Gly)(H2O)]·NO3·H2O,(Dppz为二吡啶并3,2-a;2′,3′-c]吩嗪,Gly为L-甘氨酸)。该配合物晶体属于单斜晶系,P21/c空间群,a=2.1588(4)nm,b=0.7216(13)nm,c=1.4219(3)nm,β=108.648(2)°。配合物分子中五配位的中心金属铜离子处于变形四方锥配位环境。紫外吸收光谱与荧光光谱分析表明,该配合物通过嵌入模式与DNA结合,并在还原剂存在下能显著的切割超螺旋DNA。 |
| 关 键 词： | 二吡啶并[3，2-a 2′，3′-c]吩嗪 三元铜配合物 DNA结合 DNA切割 |
Synthesis,Crystal Structure of A New Ternary Copper(Ⅱ)Complex and Its Interaction with DNA |
|
| ZHOU Jian-Liang,CHUN Xiao-Gai,ZHOU Lin-Jiao,CHEN Yun and ZHANG Shou-Chun.Synthesis,Crystal Structure of A New Ternary Copper(Ⅱ)Complex and Its Interaction with DNA[J].Chinese Journal of Inorganic Chemistry,2010,26(4):645-650. | |
| Authors: | ZHOU Jian-Liang CHUN Xiao-Gai ZHOU Lin-Jiao CHEN Yun and ZHANG Shou-Chun |
| Institution: | School of Chemistry and Chemical Engineering, Central South University, Changsha 410083,School of Chemistry and Chemical Engineering, Central South University, Changsha 410083,The State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,School of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 and School of Chemistry and Chemical Engineering, Central South University, Changsha 410083; The State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 |
| Abstract: | A new ternary copper(Ⅱ)complex,Cu(Dppz)(Gly)(H_2O)].NO_3·H_2O(dppz=dipyrido3,2-a:2',3'-c]phenazine,Gly=L-glycine),has been synthesized and structurally characterized.The complex crystallized in a monoclinic system with space group P2_1/c,α=2.1588(4)nm,b=0.7216(13)nm,c=1.4219(3)nm,β=108.648(2)°.The five-coordinate copper(Ⅱ)center is a distorted square pyramid.Absorption spectra and fluorescence spectra showed that there was interaction between the eopper(Ⅱ)complex and DNA through an intercalative mode.The complex exhibited efficient DNA cleavage activity in the presence of ascorbate.CCDC:767873. |
| Keywords: | dppz DNA binding DNA cleavage |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《无机化学学报》浏览原始摘要信息 | |
| 点击此处可从《无机化学学报》下载免费的PDF全文 | |