| 羟基磷灰石负载放射性18F作为分子影像纳米探针在生物医学中的应用 |
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| 引用本文： | 吴睿,卢久富,宋娟,刘存芳,张强,田光辉.羟基磷灰石负载放射性18F作为分子影像纳米探针在生物医学中的应用[J].无机化学学报,2019,35(5):891-900. |
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| 作者姓名： | 吴睿 卢久富 宋娟 刘存芳 张强 田光辉 |
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| 作者单位： | 陕西理工大学化学与环境科学学院陕西省催化基础与应用重点实验室 |
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| 基金项目： | 陕西省自然科学基金（No.2018JQ2057），陕西省教育厅科研计划（No.17JK0151），陕西理工大学博士研究基础项目（No.209020195），国家自然科学基金（No.21502109）和陕西省教育厅重点科研项目（No.18JS023，17JS027）资助 |
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| 摘 要： | 采用简便有效的方法,制备了生物兼容性强、放射性标记羟基磷灰石(HAp)纳米粒子的正电子发射计算机断层显像(PET)纳米探针。在合成HAp纳米粒子的过程中,放射性的~(18)F作为掺杂剂,占据HAp晶格中羟基位置,在短时间内牢固地标记到HAp上。~(18)F不仅标记在纳米粒子的表面,而且还通过强的化学键标记在纳米颗粒的内部。以达到提高标记量并防止辐射泄漏的目的。设计的高标记量的放射性纳米探针应用于动物实验并靶向到达脏器器官。
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| 关 键 词： | 羟基磷灰石 放射性标记 掺杂 18F |
| 收稿时间： | 2018/11/1 0:00:00 |
| 修稿时间： | 2019/3/22 0:00:00 |
Hydroxyapatite Loaded Radiolabeled 18F as Molecular Imaging Nanoprobes for Biomedical Application |
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| WU Rui,LU Jiu-Fu,SONG Juan,LIU Cun-Fang,ZHANG Qiang and TIAN Guang-Hui.Hydroxyapatite Loaded Radiolabeled 18F as Molecular Imaging Nanoprobes for Biomedical Application[J].Chinese Journal of Inorganic Chemistry,2019,35(5):891-900. |
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| Authors: | WU Rui LU Jiu-Fu SONG Juan LIU Cun-Fang ZHANG Qiang and TIAN Guang-Hui |
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| Institution: | Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China,Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China,Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China,Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China,Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China and Shaanxi Key Laboratory of Catalysis, College of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China |
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| Abstract: | Biocompatible and radiolabeled hydroxyapatite nanoparticles (HAp NPs) as positron emission tomography (PET) nanoprobes were developed by a facile and effective method. Radioactive 18F was firmly incorporated in the process of synthesis HAp as dopant by occupying hydroxyl vacancy in lattice of HAp in a short time. 18F was not only on the surface of the HAp NPs but also inner by strong chemical bond to achieve the purpose of large amounts of labelling and prevent radiation leakage. The designed high load of radiolabeled HAp NPs was applied to animal experiment and targeted to viscera organs. |
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| Keywords: | hydroxyapatite radiolabeled doping 18F |
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