| 二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2, 3, 4)的合成、结构及体外抗癌活性 |
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| 引用本文： | 邝代治,朱小明,冯泳兰,张复兴,庾江喜,蒋伍玖,谭宇星,张志坚.二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2, 3, 4)的合成、结构及体外抗癌活性[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 邝代治 朱小明 冯泳兰 张复兴 庾江喜 蒋伍玖 谭宇星 张志坚 |
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| 作者单位： | 衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学系;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院生命科学系, 衡阳 421008 |
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| 基金项目： | 湖南省自然科学基金(No.13JJ3112)和科技计划(No.2013TZ2025,2014NK3086,2014FJ3060),功能金属有机材料湖南省普通高校重点实验室开放基金资助项目(No.13K105,14K014,13K01-05,GN14K01),衡阳师范学院科学基金(No.12C45),湖南省重点学科基金和湖南省高校科技创新团队支持计划资助项目。 |
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| 摘 要： | 丁二酸、戊二酸和己二酸分别与μ-氧-双三(2-甲基-2-苯基)丙基]锡反应, 合成了3个二三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)nCO2Sn(CH2CMe2Ph)3]2(n=2 (1), 3 (2), 4 (3))。对化合物1~3进行了元素分析、红外光谱及核磁共振(1H, 13C)表征, 并通过X-射线晶体衍射分析测定晶体结构。化合物中锡与配基原子构成畸型四面体构型。试验表明, 化合物2和3均对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460的增殖具有较强的抑制作用。
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| 关 键 词： | 二[三(2-甲基-2-苯基)丙基锡]二元羧酸酯 合成 晶体结构 抗癌活性 |
| 收稿时间： | 3/9/2015 12:00:00 AM |
Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4) |
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| KUANG Dai-Zhi,ZHU Xiao-Ming,FENG Yong-Lan,ZHANG Fu-Xing,YU Jiang-Xi,JIANG Wu-Jiu,TAN Yu-Xing and ZHANG Zhi-Jian.Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4)[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | KUANG Dai-Zhi ZHU Xiao-Ming FENG Yong-Lan ZHANG Fu-Xing YU Jiang-Xi JIANG Wu-Jiu TAN Yu-Xing and ZHANG Zhi-Jian |
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| Institution: | Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China and Department of Lifes Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | |
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| Keywords: | bis[tris(2-methyl-2-phenyl) propyltin] dicarboxylate synthesis crystal structure anti-tumor activity |
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