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不同配体对钌多吡啶配合物与DNA的作用和荧光性质的影响
引用本文:张黔玲,刘剑洪,任祥忠,魏波,徐宏,张培新,刘建忠,计亮年.不同配体对钌多吡啶配合物与DNA的作用和荧光性质的影响[J].无机化学学报,2003,19(6):645-649.
作者姓名:张黔玲  刘剑洪  任祥忠  魏波  徐宏  张培新  刘建忠  计亮年
作者单位:1. 深圳大学师范学院化学与生物学系,深圳,518060
2. 中山大学化学与化工学院,广州,510275
基金项目:国家自然科学基金资助项目(No.29801005)。
摘    要:Two polypyridyl ligands DCHIP (2-hydro-3,5-dichlorophenyl-imidazo4,5-f]1,10] phenanthroline),MDHIP(2,4-dihydrophenyl-imidazo4,5-f]1,10]phenanthroline) and their ruthenium(Ⅱ) complexes Ru(phen)2MDHIP]2+ and Ru(phen)2DCHIP]2+ were prepared. Their DNA-binding properties were studied by spectroscopic methods and viscosity measurements. The results indicated that the complexes both bound to DNA by partial intercalation mode, but Ru(phen)2DCHIP]2+ exhibited stronger binding affinity for DNA than Ru(phen)2MDHIP]2+ due to the different planarities and steric effects of ligands. On the other hand, after binding to DNA, the fluorescence intensity of Ru(phen)2MDHIP]2+ decreased, while the fluorescence intensity of Ru(phen)2 DCHIP]2+ increased.

关 键 词:多吡啶钌配合物  DNA  作用机制  荧光
修稿时间:2002年12月5日

Effects of Different Ligands on the DNA-Binding and Fluorescence Properties of Complexes
ZHANG Qian-Ling,LIU Jian-Hong,REN Xiang-Zhong,WEI Bo,XU Hong,ZHANG Pei-Xin,LIU Jian-Zhong and JI Liang-Nian.Effects of Different Ligands on the DNA-Binding and Fluorescence Properties of Complexes[J].Chinese Journal of Inorganic Chemistry,2003,19(6):645-649.
Authors:ZHANG Qian-Ling  LIU Jian-Hong  REN Xiang-Zhong  WEI Bo  XU Hong  ZHANG Pei-Xin  LIU Jian-Zhong and JI Liang-Nian
Abstract:Two polypyridyl ligands DCHIP (2 hydro 3,5 dichlorophenyl imidazo phenanthroline),MDHIP(2,4 dihydrophenyl imidazophenanthroline) and their ruthenium?complexes Ru(phen)2 MDHIP]2+and Ru(phen)2DCHIP]2+were prepared. Their DNA binding properties were studied by spectroscopic methods and viscosity measurements. The results indicated that the complexes both bound to DNA by partial intercalation mode, but Ru(phen)2DCHIP]2+exhibited stronger binding affinity for DNA than Ru(phen)2 MDHIP]2+due to the different planarities and steric effects of ligands. On the other hand, after binding to DNA, the fluorescence intensity of Ru(phen)2MDHIP]2+decreased, while the fluorescence intensity of Ru(phen)2 DCHIP]2+increased.
Keywords:polypyridyl ruthenium complex  DNA  binding mechanism  fluorescence
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