| 过渡金属配合物断裂双链DNA及其机理 |
| |
| 引用本文： | 刘长林,余四旺,徐辉碧,周井炎.过渡金属配合物断裂双链DNA及其机理[J].无机化学学报,2000,16(3):374-384. |
| |
| 作者姓名： | 刘长林 余四旺 徐辉碧 周井炎 |
| |
| 作者单位： | 华中理工大学化学系!武汉430074 |
| |
| 基金项目： | 国家自然科学青年基金!（No.29871011），湖北自然科学资助!（mo.987051） |
| |
| 摘 要： | 本文讨论了过渡金属配合物导致ＤＮＡ双链断裂的各种攫氢反应及碱基氧化机理，对由水解过程促进ＤＮＡ断裂的过渡金属配合物也作了介绍。
|
| 关 键 词： | DNA 过渡金属配合物 攫氢 碱基氧化 水解 |
| 收稿时间： | 1999/7/14 0:00:00 |
| 修稿时间： | 1999/10/21 0:00:00 |
Progress on the Mechanisms for Double-Stranded DNA Scission Mediated by Transition Metal Complexes |
| |
| LIU Chang-Lin,YU Si-Wang,XU Hui-Bi and ZHOU Jing-Yan.Progress on the Mechanisms for Double-Stranded DNA Scission Mediated by Transition Metal Complexes[J].Chinese Journal of Inorganic Chemistry,2000,16(3):374-384. |
| |
| Authors: | LIU Chang-Lin YU Si-Wang XU Hui-Bi and ZHOU Jing-Yan |
| |
| Institution: | Department of Chemistry Huazhong University of Science and Technology, Wuhan 430074,Department of Chemistry Huazhong University of Science and Technology, Wuhan 430074,Department of Chemistry Huazhong University of Science and Technology, Wuhan 430074 and Department of Chemistry Huazhong University of Science and Technology, Wuhan 430074 |
| |
| Abstract: | Transition metal complex-mediated double-stranded DNA scission via hydrogen abstraction from the sugar moiety and base oxidation is reviewed. DNA hydrolytic cleavage promoted by transition metal complexes is also discussed in detail. |
| |
| Keywords: | DNA transition metal complex hydrogen abstraction base oxidation hydrolytic cleavage |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《无机化学学报》浏览原始摘要信息 |
| 点击此处可从《无机化学学报》下载免费的PDF全文 |
