| 核-隔层-壳结构Fe3O4@MoO3@mSiO2纳米载体的合成及其药物可控释放 |
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| 引用本文： | 唐冠鑫,彭红霞,胡传跃,彭秧锡.核-隔层-壳结构Fe3O4@MoO3@mSiO2纳米载体的合成及其药物可控释放[J].无机化学学报,2018,34(2):337-345. |
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| 作者姓名： | 唐冠鑫 彭红霞 胡传跃 彭秧锡 |
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| 作者单位： | 湖南人文科技学院, 材料与环境工程学院, 精细陶瓷与粉体材料湖南省重点实验室, 娄底 417000,湖南人文科技学院, 材料与环境工程学院, 精细陶瓷与粉体材料湖南省重点实验室, 娄底 417000;中南大学材料科学与工程学院, 长沙 41000,湖南人文科技学院, 材料与环境工程学院, 精细陶瓷与粉体材料湖南省重点实验室, 娄底 417000,湖南人文科技学院, 材料与环境工程学院, 精细陶瓷与粉体材料湖南省重点实验室, 娄底 417000 |
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| 基金项目： | 国家自然科学基金（No.51704116），中国博士后科学基金项目（No.2017M612582），湖南省科技计划项目（No.2016TP1028）和湖南省教育厅科学研究项目（No.16B136）资助项目。 |
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| 摘 要： | 利用加热均匀、迅速、热平稳性好和安全性高的微波热响应来实现药物的微波可控释放。引入具有微波热响应性质、热稳定性和化学稳定性好的Mo O3作为微波吸收物质,制备了核-隔层-壳结构Fe_3O_4@MoO_3@mSiO_2纳米药物载体。研究该纳米载体对药物布洛芬(IBU)的负载和微波响应可控释放过程。该纳米载体具有高的比表面积(222 cm2·g-1)和较大的孔隙体积(0.14 cm3·g-1)可用来负载药物。同时还具有较好的磁响应性,可实现药物的靶向给药,具有相对好的微波热响应性,可通过MoO_3中间层吸收微波辐射实现药物的可控释放。结果表明,在持续微波辐射360 min时IBU的释放率达到86%,远远高于仅搅拌时的释放率。
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| 关 键 词： | Fe3O4@MoO3@mSiO2 磁性 吸波热转换性 载药 可控释放 |
| 收稿时间： | 2017/8/10 0:00:00 |
| 修稿时间： | 2017/11/2 0:00:00 |
Core-Spacer-Shell Structured Fe3O4@MoO3@mSiO2 Nanocarrier: Preparation and Controlled Release Drug |
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| TANG Guan-Xin,PENG Hong-Xi,HU Chuan-Yue and PENG Yang-Xi.Core-Spacer-Shell Structured Fe3O4@MoO3@mSiO2 Nanocarrier: Preparation and Controlled Release Drug[J].Chinese Journal of Inorganic Chemistry,2018,34(2):337-345. |
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| Authors: | TANG Guan-Xin PENG Hong-Xi HU Chuan-Yue and PENG Yang-Xi |
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| Institution: | Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Materials and Environmental Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, China,Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Materials and Environmental Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, China;School of Materials Science and Engineering, Central South University, Changsha 410083, China,Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Materials and Environmental Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, China and Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Materials and Environmental Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, China |
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| Abstract: | MoO3 interlayered Fe3O4@MoO3@mSiO2 core-spacer-shell structured drug nanocarrier was constructed to investigate loading and controllable release properties of ibuprofen (IBU). They possess high surface area of 222 cm2·g-1, provide large accessible pore volume of 0.14 cm3·g-1 for adsorption of drug molecules. At the same time they also have good magnetic responsiveness for drug targeting under foreigen magnetic under foreign magnetic fields, relatively good microwave heating conversion behavior for controlled release by microwave-triggered which is caused by MoO3 interlayer. The IBU release of over 86% under microwave discontinuous irradiation within 360 min outclasses the only stirring release. |
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| Keywords: | Fe3O4@MoO3@mSiO2 magnetic microwave heating conversion behavior loading drug controlled release |
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