新法合成手性磷酸锌钠

对合成手性磷酸锌钠(NaZnPO₄·H₂O) (CZP)的新方法进行了研究，用Na₃PO₄·12H₂Oand ZnSO₄·7H₂O作为起始原料，聚乙二醇-400（PEG-400）为表面活性剂，通过一步低热固相反应得到了手性磷酸锌钠。用TG/DTG，XRD, TEM 及 SEM表征了产物。实验结果表明，Na₃PO₄·12H₂O与ZnSO₄·7H₂O的配比采用不同的p/Zn比（0.9～1.15），在60 ℃下陈化不同的时间(2.0～8.0 h) 所得到的NaZnPO₄·H₂O，除了结晶度稍为不同之外，晶体的手性结构是一样的。对照实验的结果显示陈化温度及阴离子调控着NaZnPO₄·H₂O的对映体形态。即，若以ZnSO₄·7H₂O或Zn(NO₃)₂·6H₂O为锌源，当反应混合物在60 ^oC陈化时，生成产物的结构是空间群为 P6₁22 的第一种手性结构，当反应混合物在室温陈化时，生成产物的结构则是空间群为 P6₅22 的第二种手性结构。

A Simple and Novel Route for The Preparation of Chiral Sodium Zincophosphate

A simple and novel route for the preparation of chiral sodium zincophosphate (NaZnPO₄·H₂O) (CZP) was studied, and the target product was obtained with Na₃PO₄·12H₂O and ZnSO₄·7H₂O as raw materials and polyethylene glycol‐400 (PEG‐400) as a surfactant via one step low heat solid state reaction. The product was characterized with TG/DTG, XRD, TEM and SEM. The experimental results showed that the NaZnPO₄·H₂O, which was all obtained from different P/Zn atomic ratios (0.9–1.15) of Na₃PO₄·12H₂O to ZnSO₄·7H₂O and different ageing time (2.0–8.0 h) at 60 °C, had the same chiral crystal structures except slight difference in their crystallinity. The comparison experimental results suggest that the ageing temperature and anion control the enantiomorphism of NaZnPO₄·H₂O, that is, if ZnSO₄·7H₂O or Zn(NO₃)₂·6H₂O were used as Zn source, the first chiral structure of space group P6₁22 was formed when the reaction mixture was aged at 60 °C, and the second chiral structure of space group P6₅22 was got when the reaction mixture was aged at room temperature.