| 微波辐射下吡啶[2,3-d]嘧啶衍生物的高效合成 |
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| 引用本文： | 屠树江,吴姗姗,韩正国,郝文娟.微波辐射下吡啶[2,3-d]嘧啶衍生物的高效合成[J].中国化学,2009,27(6):1148-1152. |
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| 作者姓名： | 屠树江 吴姗姗 韩正国 郝文娟 |
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| 作者单位： | 徐州师范大学化学化工学院江苏省药用植物生物技术重点实验室, 江苏徐州221116 |
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| 摘 要： | 本文以等摩尔的芳醛，巴比妥酸（或1,3-二甲基巴比妥酸），5-氨基-2-甲基苯d]噻唑为原料，以醋酸和乙二醇为溶剂，微波辐射下多组分一锅法合成了一系列新的吡啶2,3-d]嘧啶衍生物。这种方法具有产率高，操作简便，反应时间短等优点。
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| 关 键 词： | 吡啶[2 3-d]嘧啶 合成 微波辐射 混合溶剂 |
| 收稿时间： | 2008-11-6 |
| 修稿时间： | 2008-12-21 |
An Efficient Microwave‐assisted Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives |
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| Shujiang TU,Shanshan WU,Zhengguo HAN,Wenjuan HAO.An Efficient Microwave‐assisted Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives[J].Chinese Journal of Chemistry,2009,27(6):1148-1152. |
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| Authors: | Shujiang TU Shanshan WU Zhengguo HAN Wenjuan HAO |
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| Institution: | 1. Tel./Fax: 0086‐516‐83403165;2. Key Laboratory of Biotechnology for Medicinal Plant, College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China |
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| Abstract: | A series of new pyrido2,3‐d]pyrimidine derivatives were synthesized by multi‐component reactions of equimolar amount of aromatic aldehydes with barbituric acids (barbituric acid or 1,3‐dimethylbarbituric acid) and 5‐amino‐2‐methylbenzod]thiazol in mixed solvent of glacial acetic acid and ethylene glycol without catalyst under microwave irradiation. This one‐pot method has the advantage of good yields (90% –93%), simple workup procedure and short reaction time (5 min). |
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| Keywords: | pyrido[2 3‐d]pyrimidine synthesis microwave irradiation mixed solvent |
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