| Abstract: | Enthalpy‐entropy compensation remains a mystery in chemistry and biophysics. Recent study suggested that the solvent reorganization might constitute the physical origin of the compensation, which was unfortunately not widely applicable because compensation was also observed in solid phase reactions. In this study, a general theoretical model based upon strict mathematical deduction was presented, which indicated that the redistribution of the distinguishable subspecies might be the physical origin of the enthalpy‐entropy compensation in complex systems. As examples, the enthalpy‐entropy compensations in solvation and surface adsorption were discussed. |
