羟丙基-β-环糊精磁性复合微粒的合成及作为阿霉素载体的体外释药研究

羟丙基-β-环糊精因具有内部疏水和外部亲水锥形圆筒空腔结构和良好的生物相容性在磁性药物载体方面有潜在应用价值。本研究将羟丙基-β-环糊精修饰在超顺磁性纳米四氧化三铁粒子表面制备磁性复合微粒，用红外光谱，透射电镜，振动磁强计，电感耦合等离子发射等方法对该复合微粒进行了表征，并将其用于抗肿瘤药物阿霉素的体外载药与释药实验研究。结果表明该复合微粒的粒径大小在10-20nm，饱和磁化强度59.9 emu/g，铁含量55.4%。对阿霉素的载药量为87.8 μg/mg。体外释药结果显示载药复合粒子在PBS中1天，4天，10天的累积释药量分别为35.5%, 49.3%, 76.5%，表明该载体具有一定的药物缓释功能。由此可知，羟丙基-β-环糊精磁性复合微粒可作为磁性靶向给药系统的有效载体。

Magnetic HP‐β‐CD Composite Nanoparticle: Synthesis,Characterization and Application as a Carrier of Doxorubicin in vitro

Hydroxylpropyl‐β‐cyclodextrin (HP‐β‐CD) was introduced to the surface of magnetic nanoparticles in the presence of NH₃·H₂O to synthesize magnetic HP‐β‐CD composite nanoparticles, which were used as a carrier in magnetic targeted drug delivery. The composite nanoparticles were characterized by FTIR, ICP‐AES, TEM and VSM. The results showed that the iron content in the composite nanoparticles was 55.4%. The range of size is 10–20 nm and the magnetization is 59.9 emu/g. The capacity of composite nanoparticles for doxorubicin adsorption is 87.8 µg/mg after incubation for 72 h. The cumulative percentage of released doxorubicin in PBS buffer (pH=7.4) in 1, 4, 10 d were 35.5%, 49.3% and 76.5%, respectively. Thus, the magnetic HP‐β‐CD composite nanoparticles could be a potential carrier in the magnetic targeted drug delivery.