An Efficient and Simple Method for Stereoselective Synthesis of N‐Substituted Iminosugars from D‐Xylose Derivative |
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| Authors: | Jichao Zhang Wen Yuan Xiaofeng Ma Haibo Wang Huawu Shao |
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| Institution: | 1. Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China;2. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A series of new N‐substituted iminosugars were successfully synthesized through a general synthetic route from D‐xylose derivative. This approach provided a convenient access to the synthesis of N‐alkylated iminosugars as potential glucosidase inhibitors, which included a reaction of reductive amination. Various N‐alkylated iminosugars were prepared in good yields with high stereoselectivity. |
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| Keywords: | iminosugars stereoselective synthesis N‐alkylation reductive amination Michael addition |
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