| Catalytic Conversion of 2-Naphthol to 2-Hydroxy-1,4-naphthoquinone Under Mild Conditions |
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| 作者姓名： | 阎雁 郭红卫 菅文平 杨克儿 佟珊玲 方赤光 李青 常新 |
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| 作者单位： | Department of Chemistry，Shantou University，Shantou，Guangdong 515063，China，College of Chemistry，Jilin University，Changchun，Jilin 130023，China，College of Chemistry，Jilin University，Changchun，Jilin 130023，China，Department of Chemistry，Shantou University，Shantou，Guangdong 515063，China，Department of Chemistry，Shantou University，Shantou，Guangdong 515063，China，The Sanitary Detect Center of Jilin Province，Changchun，Jilin 130012，China，The Sanitary Detect Center of Jilin Province，Changchun，Jilin 130012，China，The Sanitary Detect Center of Jilin Province，Changchun，Jilin 130012，China |
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| 摘 要： | Introduction 2-Hydroxy-1,4-naphthoquinone (HNQ), existing in natural plants,1,2 is popularly separated and purified as dye or pigment. Recent research results show that, with the function to prevent the formation of protein coenzyme of HIV-I, HNQ can inhibit HIV virus from copying and propagating,3,4 HNQs derivatives and di-chloroallyl lawsone are also the inhibitor for RNA syn-thesis of cancer.5 It is well known that there is a rela-tionship between the side chain attached to HNQ an…
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| 关 键 词： | 2-萘酚 2-羟基-1 4-萘醌 氧化反应 卟啉铁氯化物 催化转化 |
Catalytic Conversion of 2-Naphthol to 2-Hydroxy-1,4-naphthoquinone Under Mild Conditions |
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| YAN,Yan,a.Catalytic Conversion of 2-Naphthol to 2-Hydroxy-1,4-naphthoquinone Under Mild Conditions[J].Chinese Journal of Chemistry,2004,22(5):487-491. |
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| Authors: | YAN Yan a |
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| Abstract: | 2‐Hydroxy‐1.4‐naphthaquinone (HNQ) was selectively synthesized from catalytic oxidation of 2‐naphthol by molecular oxygen over tetra(4‐methoxyl‐phenyl)porphyrinate iron(III) chloride (TMOPPFeCl) catalyst in an alkali methanol solution under mild conditions. The influences of solvents, temperature, time, as well as amounts of catalysts and alkali were studied. The quantitative data show that 32.9% of 2‐naphthol (0.093 mol/dm3) was catalytically converted to HNQ with the selectivity of 100% at 323 K for 9 h over TMOPPFeCl catalyst (2.54→10?4 mol/dm3) in alkali media (30 mL of methanol containing 2.5 mol/dm3 of NaOH) by flowing molecular oxygen (flowing rate of 45 mL/min). |
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| Keywords: | porphyrinate iron chloride 2-naphthol oxygen oxidation 2-hydroxy-1 4-naphthoquinone |
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