An Efficient Synthesis of 2‐Substituted Benzoxazoles via RuCl3·3H2O Catalyzed Tandem Reactions in Ionic Liquid |
| |
| Authors: | Xuesen Fan Yan He Yangyang Wang Xinying Zhang Jianji Wang |
| |
| Institution: | School of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, China |
| |
| Abstract: | An efficient synthesis of 2‐substituted benzoxazoles through RuCl3·3H2O catalyzed, air oxidized tandem reactions of 2‐aminophenols and aldehydes in bmim]BF4 was developed. This synthetic strategy has such advantages as mild reaction conditions, cost‐free oxidant, readily available starting materials, and recyclable catalyst and solvent. As an application, it was successfully used in the synthesis of the unreported 5‐(benzoxazol‐2‐yl)‐2′‐deoxyuridines with potential biological activities. |
| |
| Keywords: | 2‐substituted benzoxazoles ruthenium chloride tandem reaction ionic liquids nucleoside |
|
|
