| Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes |
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| 引用本文： | 古琴,乐学义,林庆斌,廖升荣,马雪丹,冯小龙.Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes[J].中国化学,2007,25(6):791-796. |
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| 作者姓名： | 古琴 乐学义 林庆斌 廖升荣 马雪丹 冯小龙 |
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| 作者单位： | [1]Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China [2]Center of Analysis and Measurement, Zhongshan University, Guangzhou, Guangdong 510275, China |
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| 基金项目： | Project supported by the Natural Science Foundation of Guangdong Province （No. 04105986）. |
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| 摘 要： | Four new ternary complexes： Cu（IP）（L-Val）（H2O）]ClO4·1.5H2O（1）, Cu（IP）（L-Leu）（H2O）]ClO4（2）, Cu（IP）（L-Tyr）（H2O）]ClO4·H2O（3） and Cu（IP）（L-Trp）（H2O）]ClO4·1.5H2O（4） have been synthesized and character/zed by elementa/analysis, molar conductivity, infrared absorption spectroscopy, electronic absorption spectroscopy and cyclic voltammetry, where IP=imidazo4,5-f]1,10] phenanthroline, L-Val=L-valinate, L-Leu=L-leucinate, L-Tyr=L-tyrosinate and L-Trp=L-tryptophanate. Complex 3 was structurally characterized by X-ray diffraction method, which crystallizes in orthorhornbic space group P21212 in a unit cell of dimensions a=3.0567（4） nm, b=0.74079（9） nm, c= 1.06198（13） nm, V=2.4047（5） nm^3, Z=4,μ=0.1084 cm^-1. The SOD-like activities of catalytic disrnutation of superoxide anions （O2^-· ） by the complexes were determined by means of modified nitroblue tetrazolium （NBT） photoreduction. The IC50 values of complexes 1, 2, 3 and 4 are 0.072, 0.147, 0.429 and 0.264 μmol·L^-1, respectively
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| 关 键 词： | 三元铜配合物 L-氨基酸 超氧化物岐化酶 合成 表征 酶活性 |
| 修稿时间： | 2006-06-232007-03-07 |
Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes |
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| GU, Qin LE, Xue-Yi LIN, Qing-Bin LIAO, Sheng-Rong MA, Xue-Dan FENG, Xiao-Long.Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes[J].Chinese Journal of Chemistry,2007,25(6):791-796. |
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| Authors: | GU Qin LE Xue-Yi LIN Qing-Bin LIAO Sheng-Rong MA Xue-Dan FENG Xiao-Long |
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| Institution: | a Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China; b Center of Analysis and Measurement, Zhongshan University, Guangzhou, Guangdong 510275, China |
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| Abstract: | Four new ternary complexes: Cu(IP)(L‐Val)(H2O)]ClO4·1.5H2O ( 1 ), Cu(IP)(L‐Leu)(H2O)]ClO4 ( 2 ), Cu(IP)(L‐Tyr)(H2O)]ClO4·H2O ( 3 ) and Cu(IP)(L‐Trp)(H2O)]ClO4·1.5H2O ( 4 ) have been synthesized and characterized by elemental analysis, molar conductivity, infrared absorption spectroscopy, electronic absorption spectroscopy and cyclic voltammetry, where IP=imidazo4,5‐f]1,10] phenanthroline, L‐Val=L‐valinate, L‐Leu=L‐leucinate, L‐Tyr=L‐tyrosinate and L‐Trp=L‐tryptophanate. Complex 3 was structurally characterized by X‐ray diffraction method, which crystallizes in orthorhombic space group P21212 in a unit cell of dimensions a=3.0567(4) nm, b=0.74079(9) nm, c=1.06198(13) nm, V=2.4047(5) nm3, Z=4, μ=0.1084 cm?1. The SOD‐like activities of catalytic dismutation of superoxide anions (O?2) by the complexes were determined by means of modified nitroblue tetrazolium (NBT) photoreduction. The IC50 values of complexes 1 , 2 , 3 and 4 are 0.072, 0.147, 0.429 and 0.264 µmol·L?1, respectively. |
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| Keywords: | ternary copper（Ⅱ） complex superoxide dismutase （SOD） SOD-like activity |
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