Synthesis and Microbial Studies of New Pyridine Derivatives-Ill

2-Amino substituted benzothiazole 4a--4I and p-acetamidobenzenesulfonyl chloride 2 were used to prepare 2-（p-aminophenylsulfonamido） substituted benzothiazole 6a--6I using mixture of pyridine and acetic anhydride which formed an electrophilic complex （N-acetyl pyridinium） to facilitate condensation to give desired product by removal of HC1. 2-{p-（3-Carboxypyrid-2-y1）amino]phenylsulfonamido}benzothiazoles 8a--81 were synthesized from 2-chloropyridine-3-carboxylic acid 7 and 6a--6I in 2-ethoxy ethanol using Cu-powder and K2CO3. Acid chlorides 9a--91 were condensed with 2-hydroxyethyl piperazine 10 and 2,3-dichloropiperazine 11 for amide deriva- tives 2-（p-（（3-（4-（2-hydroxyethy1）piperazin-1-ylcarbonyl）pyrid-2-y1）amino）phenylsulfonamido）benzothiazoes 12a -121 and 2-{p-3-（2,3-dichloropiperazin-l-ylcarbonyl）pyrid-2-ylamino]phenylsulfonamido}benzothiazoles 13a- 131 respectively. The structures of the new compounds have been established on the basis of their chemical analysis and spectral data （IR, 1↑H NMR and mass）. All the compounds have been screened for their antibacterial and antifungal activities.

Synthesis and Microbial Studies of New Pyridine Derivatives-Ill

2‐Amino substituted benzothiazole 4a – 4l and p‐acetamidobenzenesulfonyl chloride 2 were used to prepare 2‐(p‐aminophenylsulfonamido) substituted benzothiazole 6a – 6l using mixture of pyridine and acetic anhydride which formed an electrophilic complex (N‐acetyl pyridinium) to facilitate condensation to give desired product by removal of HCl. 2‐{p‐(3‐Carboxypyrid‐2‐yl)amino]phenylsulfonamido}benzothiazoles 8a – 8l were synthesized from 2‐chloropyridine‐3‐carboxylic acid 7 and 6a – 6l in 2‐ethoxy ethanol using Cu‐powder and K₂CO₃. Acid chlorides 9a – 9l were condensed with 2‐hydroxyethyl piperazine 10 and 2,3‐dichloropiperazine 11 for amide derivatives 2‐(p‐((3‐(4‐(2‐hydroxyethyl)piperazin‐1‐ylcarbonyl)pyrid‐2‐yl)amino)phenylsulfonamido)benzothiazoles 12a – 12l and 2‐{p‐3‐(2,3‐dichloropiperazin‐1‐ylcarbonyl)pyrid‐2‐ylamino]phenylsulfonamido}benzothiazoles 13a – 13l respectively. The structures of the new compounds have been established on the basis of their chemical analysis and spectral data (IR, ¹H NMR and mass). All the compounds have been screened for their antibacterial and antifungal activities.