含噻唑和1,2,3-三唑环的硫代磷酸肟酯的合成与生物活性

为了寻找高效、低毒的新型农用化学品，以2-氯-5-(氯甲基)噻唑为起始原料，设计合成了一系列新型含1,2,3-三唑和噻唑杂环的肟醚硫代磷酸酯衍生物，采用IR, 1H NMR, 31P NMR, MS和元素分析对其进行了结构表征。初步生物活性测试结果表明：该系列化合物具有中等程度的杀虫和杀菌活性。

Synthesis and Biological Activities of Novel Thiophosphoryl Oximates Containing Thiazole and 1,2,3‐Triazole Rings

In order to find novel high activity and low toxicity agrochemicals, a series of novel thiophosphoryl oximates containing thiazole and 1,2,3‐triazole rings 4 were synthesized by the reactions of 1‐{1‐(2‐chlorothiazol‐5‐ yl)methyl]‐5‐methyl‐1H‐1,2,3‐triazol‐4‐yl}ethanone oxime with various asymmetric thiophosphoryl chlorides. Their structures were confirmed by IR, ¹H NMR, ³¹P NMR, EI‐MS and elemental analyses. The target compounds existed as E‐configuration, which was deduced by NMR analysis and by comparison with their pyridyl analog determined by X‐ray diffraction. The results of preliminary bioassay indicate that some of title compounds possess moderate insecticidal and fungicidal activities.