| 具有叶绿素-a碳架的苯乙烯基取代Z/E-二氢卟吩衍生物的合成 |
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| 引用本文： | 王进军,李家柱,邬旭然,沈荣基.具有叶绿素-a碳架的苯乙烯基取代Z/E-二氢卟吩衍生物的合成[J].中国化学,2006,24(7):933-938. |
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| 作者姓名： | 王进军 李家柱 邬旭然 沈荣基 |
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| 作者单位： | Department of Applied Chemistry Yantai University，Yantai，Shandong 264005，China，Department of Applied Chemistry，Yantai University，Yantai，Shandong 264005，China，Department of Applied Chemistry，Yantai University，Yantai，Shandong 264005，China，School of Nano Engineering，Inje University，Pusan，South Korea |
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| 基金项目： | Project supported by Ministry of the Science，Technology of China as a cooperative project between China and Korea(2002) |
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| 摘 要： | The Wittig reaction of methyl pyropheophorbide-d 2,obtained from methyl pyropheophorbide-a 1,with ben-zyltriphenylphosphonium bromide was performed to yield isomers 3a and 3b.The Vilsmeier reaction of nickelcomplex 4 or 7 with 3-dimethylaminoacrolein in the presence of phosphoryl chloride was carried out to form20-meso-2'-formylvinylpyropheophorbide-a 5 or 8,which was reacted with Wittig reagent to afford nickel complexisomers 6a and 6b or 9a and 9b,10a and 10b.
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| 关 键 词： | chlorophyll-α derivative chlorin Wittig reaction Vilsmeier reaction photodynamic therapy |
| 收稿时间： | 2005-10-25 |
| 修稿时间： | 2005-10-252006-03-10 |
Synthesis of Styryl-substituted Z/E-Chlorin Derivatives with Chlorophyll-a Skeleton |
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| WANG, Jin-Jun LI, Jia-Zhu WU, Xu-Ran SHIM, Yong Key.Synthesis of Styryl-substituted Z/E-Chlorin Derivatives with Chlorophyll-a Skeleton[J].Chinese Journal of Chemistry,2006,24(7):933-938. |
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| Authors: | WANG Jin-Jun LI Jia-Zhu WU Xu-Ran SHIM Yong Key |
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| Institution: | 1 Department of Applied Chemistry, Yantai University, Yantai, Shandong 264005, China ;2 School of Nano Engineering, Inje University, Pusan, South Korea |
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| Abstract: | The Wittig reaction of methyl pyropheophorbide-d 2,obtained from methyl pyropheophorbide-a 1,with ben- zyltriphenylphosphonium bromide was performed to yield isomers 3a and 3b.The Vilsmeier reaction of nickel complex 4 or 7 with 3-dimethylaminoacrolein in the presence of phosphoryl chloride was carried out to form 20-meso-2'-formylvinylpyropheophorbide-a 5 or 8,which was reacted with Wittig reagent to afford nickel complex isomers 6a and 6b or 9a and 9b,10a and 10b. |
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| Keywords: | chlorophyll-a derivative chlorin Wittig reaction Vilsmeier reaction photodynamic therapy |
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