Synthesis, Crystal Structure and Biological Activities of O, O-Dialkyl α-[1-（2-Chlorothiazol-5-ylmethyl）-5-methyl- 1 H-1,2,3-triazol-4-ylcarbonyloxy]alkylphosphonates

In order to search for novel agrochemicals with high activity and low toxicity, a series of phosphonate derivatives containing 1,2,3-triazole and thiazole rings were designed and synthesized using 2-chloro-5-（chloromethyl）- thiazole as the starting material. Their structures were confirmed by IR, ^1H NMR, ^31p NMR, EI-MS or ESI-MS and elemental analyses. The crystal structure of 7a was determined by single crystal X-ray diffraction. Preliminary bioassays indicated that most of the target compounds did not display insecticidal activities, but a fraction of them possessed herbicidal and fungicidal activities to some extent.

Synthesis,Crystal Structure and Biological Activities of O,O‐Dialkyl α‐[1‐(2‐Chlorothiazol‐5‐ylmethyl)‐5‐methyl‐ 1H‐1,2,3‐triazol‐4‐ylcarbonyloxy]alkylphosphonates

In order to search for novel agrochemicals with high activity and low toxicity, a series of phosphonate derivatives containing 1,2,3‐triazole and thiazole rings were designed and synthesized using 2‐chloro‐5‐(chloromethyl)‐ thiazole as the starting material. Their structures were confirmed by IR, ¹H NMR, ³¹P NMR, EI‐MS or ESI‐MS and elemental analyses. The crystal structure of 7a was determined by single crystal X‐ray diffraction. Preliminary bioassays indicated that most of the target compounds did not display insecticidal activities, but a fraction of them possessed herbicidal and fungicidal activities to some extent.