Lanthanide Amide-catalyzed Aza-Henry Reaction of N-Tosyl Imines with Nitroalkanes |
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| Authors: | ZHANG Lijun WU Hongping SU Shunpeng WANG Shaowu |
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| Institution: | Anhui Key Laboratory of Functional Molecular Solids,Institute of Organic Chemistry,School of Chemistry and Materials Science,Anhui Normal University,Wuhu,Anhui 241000,China |
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| Abstract: | In the presence of 10 mol% lanthanide amide (Me3Si)2N]3Ln(µ‐Cl)Li(THF)3, the aza‐Henry reaction of N‐tosyl imines with nitroalkanes (1:5 molar ratio) could be performed in good yields. The lanthanide amide‐catalyzed aza‐Henry reaction has the features of mild reaction conditions, tolerance of a variety of aromatic aldehyde‐derived imines and nitroalkanes, short time and good chemical yields. A catalytic mechanism for the reaction was also proposed. |
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| Keywords: | lanthanide amide aza-Henry reaction N-tosyl imine nitroalkane catalysis |
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