| A New Solution—phase Parallel Synthesis of 2—Alkyamino—3—aryl—5—phenylmethylene—3,5—dihydro—4H—imidazol—4—ones |
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| 作者姓名： | DING Ming-Wu SUN Yong LIU Xiao-Peng LIU Zhao-Jie |
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| 作者单位： | InstituteofOrganicSynthesis,CentralChinaNormalUniveristy,Wuhan,Hubei430079,China |
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| 摘 要： | Thirteen new 2-alkylaminoimidazolones(4) wre rapidly synthesized by a new solution-phase parallel synthetic method,which includes aza-Wittig reaction of iminophosphorane(1) with aromatic isocyanate to give carbodi-imide(2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion.The products were confirmed by ^1H NMR,MS,IR and X-ray crystallographic analysis.The unusual selectivity of the cyclization was probably due to the deometry of the guanidine intermediate.
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| 关 键 词： | 液相合成 2－烷基氨基－3－芳基－5－苯基亚甲基－3 5－二氢化－4H－咪唑－4－酮 杂环化合物 芳香族异氰酸盐 |
A New Solution‐phase Parallel Synthesis of 2‐Alkylamino‐3‐aryl‐5‐phenylmethylene‐3,5‐dihydro‐4H‐imidazol‐4‐ones |
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| DING,Ming-Wu SUN,Yong LIU,Xiao-Peng LIU,Zhao-Jie.A New Solution‐phase Parallel Synthesis of 2‐Alkylamino‐3‐aryl‐5‐phenylmethylene‐3,5‐dihydro‐4H‐imidazol‐4‐ones[J].Chinese Journal of Chemistry,2003,21(5):577-580. |
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| Authors: | Ding Ming‐Wu Sun Yong Liu Xiao‐Peng Liu Zhao‐Jie |
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| Abstract: | Thirteen new 2‐alkylaminoimidazolones (4) were rapidly synthesized by a new solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane (1) with aromatic iso‐cyanate to give carbodi‐imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X‐ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate. |
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| Keywords: | solution‐phase parallel synthesis 2‐alkylamino‐3‐aryl‐5‐phenylmethylene‐3 5‐dihydro‐4H‐imidazol‐4‐ones aza‐Wittig reaction |
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