| A New Solution-phase Parallel Synthesis of 2-Alkylamino-3-aryl-5-phenylmethylene-3,5-dihydro-4H-imidazol-4-ones |
| |
| 作者姓名： | 丁明武 孙勇 刘小鹏 刘钊杰 |
| |
| 作者单位： | Institute of Organic Synthesis，Central China Normal University，Wuhan，Hubei 430079，China，Institute of Organic Synthesis，Central China Normal University，Wuhan，Hubei 430079，China，Institute of Organic Synthesis，Central China Normal University，Wuhan，Hubei 430079，China，Institute of Organic Synthesis，Central China Normal University，Wuhan，Hubei 430079，China |
| |
| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 10 2 0 0 1) |
| |
| 摘 要： | IntroductionImidazolonesareimportantheterocyclesbearingfungici dal,anti inflammotoryandangiotensinIIantagonisticalactiv ities.1 4 Someof 2 alkylaminoimidazolonesexhibitgoodan tibacterialactivities,5whereasothersshowpotentialantiviralandantitumoractivities.6 Untilnow ,manyofthenewderiva tivesofimidazoloneshavebeensynthesizedtoevaluatetheirbiologicalandpharmaceuticalactivities .Recently ,combinatorialsynthesisoflibrariescontainingsmallorganicmoleculeshasbecomearapidevolvingareaofresearch .7,8…
|
A New Solution-phase Parallel Synthesis of 2-Alkylamino-3-aryl-5-phenylmethylene-3,5-dihydro-4H-imidazol-4-ones |
| |
| Abstract: | Thirteen new 2 alkylaminoimidazolones (4) were rapidly synthesized by a new solution phase parallel synthetic method, which includes aza Wittig reaction of iminophosphorane (1) with aromatic isocyanate to give carbodi imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate. |
| |
| Keywords: | solution phase parallel synthesis 2 alkylamino 3 aryl 5 phenylmethylene 3 5 dihydro 4 H imidazol 4 ones aza Wittig reaction |
| 本文献已被 CNKI 等数据库收录！ |
