| GaI_3 Catalyzed Tetrahydropyranylation of Alcohols and Phenols |
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| 作者姓名： | 孙培培 胡志新 |
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| 作者单位： | College of Chemistry and Environmental Science，Nanjing Normal University，Nanjing，Jiangsu 210097，China，College of Chemistry and Environmental Science，Nanjing Normal University，Nanjing，Jiangsu 210097，China |
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| 基金项目： | Project supported by the Natural Science Foundation of the Education Department of Jiangsu province (No. 03KJD150109). |
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| 摘 要： | Introduction Tetrahydropyranylation is an efficient method for the protection of hydroxyl group in organic synthesis due to the stability of the tetrahydropyranyl acetals because they are stable under a variety of reaction conditions such as alkaline media, Grignard reagents, lithium al-kyls, metal hydrides, oxidative reagents, alkylating and acylating reagents.1 Tetrahydropyranyl acetals are gen-erated by a nucleophilic addition of alcohols or phenols to 3,4-dihydro-2H-pyran (DHP). A variet…
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GaI3 Catalyzed Tetrahydropyranylation of Alcohols and Phenols |
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| SUN,Pei-Pei HU,Zhi-Xin.GaI_3 Catalyzed Tetrahydropyranylation of Alcohols and Phenols[J].Chinese Journal of Chemistry,2004(11). |
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| Authors: | SUN Pei-Pei HU Zhi-Xin |
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| Institution: | SUN,Pei-Pei* HU,Zhi-Xin |
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| Abstract: | In dichloromethane, the nucleophilic addition of alcohols or phenols to 3,4-dihydro-2H-pyran (DHP) was cata-lyzed effectively by gallium triiodide which was generated in situ by the reaction of gallium metal and iodine to give the corresponding tetrahydropyranyl acetals in good to excellent yields. |
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| Keywords: | gallium triiodide alcohol or phenol 2-alkoxy(aryloxy)tetrahydropyran the protection of hydroxyl group |
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