| Solid Phase Synthesis of 2-Substituted 1,3-Oxazin-6-ones Using Resin-bound Cyclic Malonic Acid Ester |
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| 作者姓名： | 刘占祥 阮秀秀 黄宪 |
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| 作者单位： | [1]DepartmentofChemistry,ZhejiangUniversity（XixiCampus）,Hangzhou,Zhejiang310028,China [2]StateKeyLaboratoryofOrganometallicChemistry,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 20072032). |
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| 摘 要： | A facile solid phase synthesis of 2-substituted 1,3-oxazin-6-ones using polymer-supported Meldrum‘s acid has been reported. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with amide, afforded the corresponding polymer-supported acylaminomethylene cyclic malonic acid ester, which upon thermal treatment led to 1, 3-oxazin-6-ones in good yields and with high purity.
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| 关 键 词： | 固相合成 1，3-嗪-6-酮 Meldrum＇s acid 氨基化合物 取代 |
Solid Phase Synthesis of 2-Substituted 1,3-Oxazin-6-ones Using Resin-bound Cyclic Malonic Acid Ester |
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| LIU,Zhan-Xianga RUAN,Xiu-Xiua HUANG,Xian,a,b a.Solid Phase Synthesis of 2-Substituted 1,3-Oxazin-6-ones Using Resin-bound Cyclic Malonic Acid Ester[J].Chinese Journal of Chemistry,2004,22(2):212-214. |
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| Authors: | LIU Zhan-Xianga RUAN Xiu-Xiua HUANG Xian a b a |
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| Institution: | Xixi Campus |
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| Abstract: | A facile solid phase synthesis of 2-substituted 1,3-oxazin-6-ones using polymer-supported Meldrums acid has been reported. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent dou-ble substitution with amide, afforded the corresponding polymer-supported acylaminomethylene cyclic malonic acid ester, which upon thermal treatment led to 1, 3-oxazin-6-ones in good yields and with high purity. |
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| Keywords: | solid phase synthesis Meldrums acid 1 3-oxazin-6-one |
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