| Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate |
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| 作者姓名： | 过玮 林洪 刘利民 郭治安 宋俊峰 |
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| 作者单位： | GUO，Wei，a LIN，Hong b LIU，Li Min a GUO，Zhi An a SONG，Jun Feng a a Department of Chemistry，Northwest University，Xi'an，Shaanxi 710069，China b Department of Chemistry，Yuxi Normal College，Yuxi，Yunnan 653100 |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No.2 9875 0 17) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＣｈｌｏｒｄｉａｚｅｐｏｘｉｄｅ (7 ｃｈｌｏｒｏ 2 ｍｅｔｈｙｌａｍｉｎｏ 5 ｐｈｅｎｙｌ 3Ｈ 1,4 ｂｅｎｚｏｄｉａｚｅｐｉｎｅ 4 ｏｘｉｄｅ)ｓｈｏｗｉｎｇｐｏｗｅｒｆｕｌａｎ ｔｉａｎｘｉｅｔｙｅｆｆｅｃｔｈａｓｂｅｅｎｗｉｄｅｌｙｕｓｅｄａｓａｐｓｙｃｈｏｔｈｅｒａｐｅｕ ｔｉｃｄｒｕｇ .Ｃｏｎｓｅｑｕｅｎｔｌｙ ,ｔｈｅｎｅｅｄａｒｏｓｅｆｏｒｓｅｎｓｉｔｉｖｅａｎｄｒａｐｉｄｄｅｔｅｒｍｉｎａｔｉｏｎｏｆｃｈｌｏｒｄｉａｚｅｐｏｘｉｄｅｉｎｂｌｏｏｄ ,ｕｒｉｎｅａｎ…
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| 关 键 词： | 7-氯-2-甲氨基-5-苯基-3H-1 4-苯并二氮杂草-4-氧化物 应用 催化曲线 K2S2O8 催化合成 |
Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate |
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| GUO,Wei,a LIN,Hong b LIU,Li Min a GUO,Zhi An a SONG,Jun Feng a a.Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate[J].Chinese Journal of Chemistry,2002,20(5):502-508. |
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| Authors: | GUO Wei a LIN Hong b LIU Li Min a GUO Zhi An a SONG Jun Feng a a |
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| Institution: | GUO,Wei,a LIN,Hong b LIU,Li Min a GUO,Zhi An a SONG,Jun Feng a a Department of Chemistry,Northwest University,Xi'an,Shaanxi 710069,China b Department of Chemistry,Yuxi Normal College,Yuxi,Yunnan 653100 |
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| Abstract: | Polarographic catalytic wave of chlordiazepoxide in the presence of K2S2O8 was studied in aqueous and DMF/H2O mixed solutions. The results showed that a single reduction wave in alkaline medium was the reduction of the N = C bond in 1,2‐position of chlordiazepoxide via an intermediate free radical in two one‐electron successive additions. When K2S2O8 was present, the free radical of the N = C bond was oxidized to regenerate the original, producing a parallel catalytic wave of chlordiazepoxide. It was determined that the apparent rate constant kf of the oxidation reaction was 3.2 × 103 mol?1·L·s?1. Using the catalytic wave the trace of chlordiazepoxide can be determined by linear‐potential scan polarography. In NH3/NH4Cl (pH 10.2 ± 0.1, 0.12 mol/L)/K2S2O8(0.016 mol/L) supporting electrolyte, the second‐order derivative peak current of the catalytic wave was rectilinear to chlordiazepoxide concentration in the range of 3.20 × 10?8‐1.60 × 10?7, 1.60 × 10?7‐1.44×10?6 and 1.44×10?6‐1.44x 10?5 mol/L, respectively. The limit of detection was 9.0×10?9 mol/L. |
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| Keywords: | chlordiazepoxide persulfate polarographic catalytic wave free radical |
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