| Glucose-lowering Activity of Amino Acid-N-phosphonic Acid Oxovanadium Complexes and Its Interaction with DNA |
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| 作者姓名： | 刘巨涛 范圣第 李传碧 李德谦 |
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| 作者单位： | College of Life Science Dalian Nationalities University，Dalian，Liaoning 116600，China Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun，Jilin 130022，China，College of Life Science，Dalian Nationalities University，Dalian，Liaoning 116600，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun，Jilin 130022，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun，Jilin 130022，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China(No.20171011). |
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| 摘 要： | Vanadium has well-documented lowering glucose properties both in vitro and in vivo.The design of newoxovanadium(IV) coordination compounds,intended for use as insulin-enhancing agents in the treatment of diabe-tes mellitus,can potentially benefit from a synergistic approach,in which the whole complex has more than an ad-ditive effect from its component parts.Biological testing with oxovanadium(IV) organic phosphonic acid,for insu-lin-enhancing potential included acute administration,by oral garage in streptozotocin (STZ) diabetic rats.Thecomplexes of oxovanadium(IV) amino acid-N-phosphonic acid exhibit higher lowering glucose activity in vivo.Theinteraction of the complexes of oxovanadium(IV) amino acid-N-phosphonic acid with DNA was investigated byagarose gel electrophoresis.The results indicated that these complexes have strong interaction with DNA.
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Glucose-lowering Activity of Amino Acid-N-phosphonic Acid Oxovanadium Complexes and Its Interaction with DNA |
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| LIU Ju-Tao FAN Sheng-Dia LI Chuan-Bib LI De-Qianba College of Life Science,Dalian Nationalities University,Dalian,Liaoning ,Chinab Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin ,China.Glucose-lowering Activity of Amino Acid-N-phosphonic Acid Oxovanadium Complexes and Its Interaction with DNA[J].Chinese Journal of Chemistry,2006(12). |
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| Authors: | LIU Ju-Tao FAN Sheng-Dia LI Chuan-Bib LI De-Qianba College of Life Science Dalian Nationalities University Dalian Liaoning Chinab Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China |
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| Institution: | LIU Ju-Tao~* FAN Sheng-Di~a LI Chuan-Bi~b LI De-Qian~ba College of Life Science,Dalian Nationalities University,Dalian,Liaoning 116600,Chinab Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin 130022,China |
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| Abstract: | Vanadium has well-documented lowering glucose properties both in vitro and in vivo.The design of new oxovanadium(IV) coordination compounds,intended for use as insulin-enhancing agents in the treatment of diabe- tes mellitus,can potentially benefit from a synergistic approach,in which the whole complex has more than an ad- ditive effect from its component parts.Biological testing with oxovanadium(IV) organic phosphonic acid,for insu- lin-enhancing potential included acute administration,by oral garage in streptozotocin (STZ) diabetic rats.The complexes of oxovanadium(IV) amino acid-N-phosphonic acid exhibit higher lowering glucose activity in vivo.The interaction of the complexes of oxovanadium(IV) amino acid-N-phosphonic acid with DNA was investigated by agarose gel electrophoresis.The results indicated that these complexes have strong interaction with DNA. |
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| Keywords: | oxovanadium amino acid-N-phosphonic acid lowering glucose activity interaction |
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