| 钯催化带有酮或醛的芳基三氟甲磺酸酯与胺或酰胺的取代反应 |
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| 引用本文： | TAO,Xiao-Chun,a.钯催化带有酮或醛的芳基三氟甲磺酸酯与胺或酰胺的取代反应[J].中国化学,2009,27(2):403-407. |
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| 作者姓名： | TAO Xiao-Chun a |
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| 作者单位： | a 华东理工大学，金属有机化学研究室，上海， 200237, 中国 ;b Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA ; |
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| 摘 要： | 各种含有酮或醛的芳基三氟甲磺酸酯在催化量的钯和膦配体的存在下与胺或酰胺发生取代反应。BINAP为配体对仲胺效果最好，MOP-型配体对伯胺和少量仲胺效果较好，Xantphos 对伯酰胺和环状仲酰胺效果好。脂肪族的仲酰胺作为亲核试剂没有得到好的结果。
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| 关 键 词： | 芳基三氟甲磺酸酯 取代反应 胺 酰胺 钯 膦配体 |
| 收稿时间： | 2008-6-5 |
| 修稿时间： | 2008-8-27 |
Palladium‐catalyzed Substitution of Ketone or Aldehyde Bearing Aryl Triflates by Amines or Amides |
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| Xiaochun TAO,Chunya DAI,Xiongjie CAO,Lisheng CAI,Victor W. PIKE.Palladium‐catalyzed Substitution of Ketone or Aldehyde Bearing Aryl Triflates by Amines or Amides[J].Chinese Journal of Chemistry,2009,27(2):403-407. |
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| Authors: | Xiaochun TAO Chunya DAI Xiongjie CAO Lisheng CAI Victor W PIKE |
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| Institution: | 1. Tel.: 0086‐021‐64253519;2. Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237, China;3. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA |
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| Abstract: | Various aryl triflates, bearing ketone or aldehyde groups, were evaluated for palladium‐mediated introduction of an amino group at the triflate position in the presence of various phosphine ligands. BINAP was best for secondary amines, MOP‐type ligand for primary or small secondary amines and Xantphos for primary or cyclic secondary amides. No ligand was found effective for acyclic secondary amides. |
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| Keywords: | aryl triflate substitution amine amide palladium phosphine ligand |
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