首页 | 本学科首页   官方微博 | 高级检索  
     检索      

A Short and Highly Stereoselective Synthesis of Cerebrosterol
作者姓名:张冬辉  周向东  周维善
作者单位:ZHANG,Dong-Hui a ZHOU,Xiang-Dong b ZHOU,Wei-Shan,a a Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China b Department of Chemistry,The Third Military Medical University,Chongqing 400038,Ch
基金项目:theNationalNaturalScienceFoundationofChina (No.2 0 0 72 0 47)
摘    要:Cerebrosterol (2 4S hydroxycholesterol,1)formedinsmallamountsinhumanandanimalbrain1fromcholes terolisimportantforcholesterolhomeostasisinthisorgan .Theexcesscholesterolisconvertedinto 2 4S hydroxy cholesterolbyauniquebrain specific 2 4S hydroxylase ,whichcouldber…

关 键 词:cerebrosterol    methyl    6α-dihydroxy  hyodeoxycholanate    diisopropylzinc    stereoselective  synthesis

A Short and Highly Stereoselective Synthesis of Cerebrosterol
ZHANG,Dong-Hui a ZHOU,Xiang-Dong b ZHOU,Wei-Shan,a a.A Short and Highly Stereoselective Synthesis of Cerebrosterol[J].Chinese Journal of Chemistry,2002,20(11):1145-1148.
Authors:ZHANG  Dong-Hui a ZHOU  Xiang-Dong b ZHOU  Wei-Shan  a a
Institution:ZHANG,Dong-Hui a ZHOU,Xiang-Dong b ZHOU,Wei-Shan,a a Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China b Department of Chemistry,The Third Military Medical University,Chongqing 400038,Ch
Abstract:The title compound, cerebrosterol, has been synthesized in five steps with 61.5% overall yield and > 99.9% de from 3α, 6α‐dimethoxymethoxyl‐5P‐cholane‐24‐al as a key intermediate, which was prepared from methyl , 6α‐dihydroxy hyodeoxy‐cholanate.
Keywords:cerebrosterol  methyl 3α  6α‐dihydroxy hyodeoxy‐cholanate  diisopropylzine  stereoselective synthesis
本文献已被 CNKI 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号