| Synthesis and Insulin—sensitizing Activity of a Series of 2—Benzyl—1,3—dicarbonyl Derivatives |
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| 引用本文： | 汤磊,冯颖,王火权,冯颖,杨玉社,嵇汝运.Synthesis and Insulin—sensitizing Activity of a Series of 2—Benzyl—1,3—dicarbonyl Derivatives[J].中国化学,2003,21(4):365-368. |
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| 作者姓名： | 汤磊 冯颖 王火权 冯颖 杨玉社 嵇汝运 |
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| 作者单位： | StateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMateriaMedica,ShanghaiInstitutesforBiologicalSciences,ChinsesAcademyofSciences,Shanghai200031,China |
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| 摘 要： | A series of 2-benzyl-1,3-dicabonyl derivatives was synthesized.Their insulin-sensitizing activity was evaluated in 3T3-L1 preadipocyte cells.Compounds3,26 and 27 were found to possess strong insulin-sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo.
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| 关 键 词： | 胰岛素 光敏活性 3T3－L1细胞 合成 |
Synthesis and Insulin-sensitizing Activity of a Series of 2-Benzyl-1,3-dicarbonyl Derivatives |
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| Tang Lei,Leng Ying,Wang Huo‐Quan,Feng Ying,Yang Yu‐She,Ji Ru‐Yun.Synthesis and Insulin-sensitizing Activity of a Series of 2-Benzyl-1,3-dicarbonyl Derivatives[J].Chinese Journal of Chemistry,2003,21(4):365-368. |
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| Authors: | Tang Lei Leng Ying Wang Huo‐Quan Feng Ying Yang Yu‐She Ji Ru‐Yun |
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| Abstract: | A series of 2 benzyl 1,3 dicabonyl derivatives was synthesized. Their insulin sensitizing activity was evaluated in 3T3 L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo. |
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| Keywords: | insulin sensitizing activity 3T3 L1 cells type 2 diabetes |
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