| Synthesis of homochiral spiro[4.4] nonane-1,6-diols |
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| 作者姓名： | 蒋耀忠 鄢明 孙健 胡文浩 李智 宓爱巧 陈新滋 |
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| 作者单位： | Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，Chengdu，Sichuan 610041，China，Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，Chengdu，Sichuan 610041，China，Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，Chengdu，Sichuan 610041，China，Department of Applied Biology and Chemical Technology，the Hong Kong Polytechnic University，Hong Kong，China，Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，Chengdu，Sichuan 610041，China，Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，Chengdu，Sichuan 610041，China，Department of Applied Biology and Chemical Technology，the Hong Kong Polytechnic University，Hong Kong，China |
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| 基金项目： | Project(29572068)supported by the National Natural Science Foundation of China. |
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| 摘 要： | Homochiral cis,cis-; cis,trans- and trans,trans-spiro4.4]nonane-1,6-diols were prepared via diastereoselective reduction of enantiomerically pure spiro4.4]nonane-1,6-dione (1) with the corresponding reducing agents: lithium n-butyldiisobutylaluminium hydride for cis,cis-diol (2) with 88% yield; BH3·THF for cis, trans-diol (3) with 91% yield; LiAlH4 for trans,trans-diol (4) with 15% yield.
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Synthesis of homochiral spiro[4.4] nonane-1,6-diols |
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| JIANG,Yao-Zhong YAN,Ming SUN,JianHU,Wen-Hao LI,Zhi MI,Ai-QiaoCHAN,Albert S. C. Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan ,China.Synthesis of homochiral spiro[4.4] nonane-1,6-diols[J].Chinese Journal of Chemistry,1998(3). |
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| Authors: | JIANG Yao-Zhong YAN Ming SUN JianHU Wen-Hao LI Zhi MI Ai-QiaoCHAN Albert S C Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu Sichuan China |
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| Institution: | JIANG,Yao-Zhong YAN,Ming SUN,JianHU,Wen-Hao LI,Zhi MI,Ai-QiaoCHAN,Albert S. C. Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China Department of Applied Biology and Chemical Technology,the Hong Kong Polytechnic University,Hong Kong,China |
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| Abstract: | |
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| Keywords: | Homochiral spiro[4 4]nonane-1 6-diol reduction |
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