| A new synthesis of cytotoxic ( )-7-epi-Goniofufurone |
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| 作者姓名： | 杨敏 李红明 赵刚 俞庆森 丁渝 |
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| 作者单位： | Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Department of Chemistry，Zhejiang University，Hangzhou，Zhejiang 310027，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 摘 要： | Cytotoxic styryl lactone, ( )-7-epi-Gonioftifurone (1), has been prepared with a new route from 3-O-benzyl-1,2-O-iso-propylidene-5-C-phenyl-β-L-ido-pentofuranose (6), a derivative of ( )-glucose. Treatment of 14 with HCl solution cleaved TBDMS and isopropylidene and simultaneously caused ring closure to afford 1 while treatment of 14 with Sc(OTf)3 only removed TBDMS to give 15.
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A new synthesis of cytotoxic ( )-7-epi-Goniofufurone |
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| YANG,Min LI,Hong-Ming ZHAO,GangYU,Qing-Sen DING,Yu.A new synthesis of cytotoxic ( )-7-epi-Goniofufurone[J].Chinese Journal of Chemistry,2000,18(2):225-231. |
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| Authors: | YANG Min LI Hong-Ming ZHAO GangYU Qing-Sen DING Yu |
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| Institution: | YANG,Min LI,Hong-Ming ZHAO,GangYU,Qing-Sen DING,Yu Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China Department of Chemistry,Zhejiang University,Hangzhou,Zhejiang 310027,China |
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| Abstract: | Cytotoxic styryl lactone, ( + )‐7‐epi‐Goniofufurone (1), has been prepared with a new route from 3‐O‐benzyl‐1, 2‐O‐isopropylidene‐5‐C‐phenyl‐β‐L‐ido‐pentofuranose (6), a derivative of (+)‐glucose. Treatment of 14 with HCl solution cleaved TBDMS and isopropylidene and simultaneously caused ring closure to afford 1 while treatment of 14 with Sc(OTf)3 only removed TBDMS to give 15. |
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| Keywords: | Furans styryl lactone cytotoxicity |
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