| Synthesis of the Active Stilbenoids by Photooxidation Reaction of trans-ε-Viniferin |
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| 摘 要： |
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| 关 键 词： | 合成 光致氧化反应 viniferin 肿瘤坏死抑制因子 2b 14b-脱氢-二白藜卢醇 Stilbenoid |
Synthesis of the active stilbenoids by photooxidation reaction of trans‐ϵ‐viniferin |
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| Authors: | Chun‐Suo Yao Mao Lin Ying‐Hong Wang |
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| Abstract: | Two new stilbenoids, cis‐?‐viniferin (3) and 2b, 14b‐dehydro‐bisresveratrol (4) were synthesized by photooxidation reaction of trans‐?‐viniferin (2) prepared from tram‐resveratrol (1). Pentamethoxyl trans‐?‐viniferin (5) and pentamethoxyl cis‐?‐viniferin (6) were also obtained by methylation of trans‐?‐viniferin (2) with (MeO)2SO2. Their structures were elucidated on the basis of spectral evidence. Compounds 3 and 4 showed potent inhibition of TNF‐α at concentrations of 10?‐5 mol.L?1 with inhibitory ratios of 51.43% and 36.64%. respectively. |
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| Keywords: | Photooxidation cis‐ϵ‐viniferin 2b 14b‐dehydro‐bisresveratrorol stilbenoid tumor necrosis factor inhibitory activity |
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