2,2-双(4-氯-2-氟苄基)丙二酸二乙酯的晶体结构和密度泛函理论研究

标题化合物是一个重要的精细化工中间体,可用于制备嘧啶类、吡唑类等产品。本文利用红外光谱(IR)、质谱(MS)、核磁共振氢谱(¹H NMR)、核磁共振碳谱(¹³C NMR)和X-射线单晶衍射对此化合物进行了表征,并在B3LYP/6-311G(d, p)模式下使用密度泛函理论(DFT)计算了此化合物的最稳定晶体结构以及最高占有分子轨道(HOMO)和最低占有分子轨道(LUMO)能量。结果表明,通过DFT优化的分子结构与X-射线单晶衍射确定的晶体结构基本一致,该化合物属于单斜方P2(1)/n空间群,晶胞参数为:a=1.563 9(10) nm, b=0.778 6(4) nm, c=1.838 2(10) nm,Z=4, ρ_c＝1.345 g·cm^-3,R=0.047 7,R_w=0.138 7。

Crystal Structure and Density Functional Theory of 2,2-Bis(4-Chloro-2-Fluorobenzyl) Diethyl Malonate

The title compound is an important fine chemical intermediate, which can be used to prepare kinds of pyrimidines and pyrazoles products. This compound was characterized by IR, MS, ¹H NMR,¹³C NMR and X-ray single crystal diffraction, and the most stable crystal structure, HOMO and LUMO energy were calculated by using density functional theory (DFT) in B3LYP/6-311G(d, p) mode. The results show that the molecular structure optimized by DFT is consistent with the crystal structure determined by X-ray single crystal diffraction. The compound belongs to the monoclinic P2(1)/n space group, its crystallographic parameters are as follows: a=1.563 9(10) nm, b=0.778 6(4) nm, c=1.838 2(10) nm, Z=4, ρ_c=1.345 g·cm^-3, R=0.047 7, R_w=0.138 7.