骨的力–电效应研究方法与进展

骨组织在受到应力作用(正常的生理活动)变形后在骨内产生电位的现象称为骨的力–电效应,它主要包括压电效应和动电效应.研究骨在动态过程中产生的电位幅值和分布特点,不仅是了解电刺激骨生长机理的必要步骤,也是实现骨治疗和重建的生理基础.它一方面是用数学方法来描述外力作用下其电位大小与应力、应变、应变率及加载速率的关系,另一方面是考察生理环境(pH值、离子浓度、温度、湿度等)对电位的影响.首先对力–电理论进行了简单的介绍,重点总结了其研究方法,包括理论模型和分离式霍普金生杆冲击、弯曲变形及缓冲液中的动态测试等实验方法.此外,对骨替代材料和牙本质领域的力–电效应研究也进行了一定的综述.

PROGRESS AND METHODS OF RESEARCH ON BONE'S STRESS-GENERATED POTENTIALS

To osseous tissue, the normal physiological activity can lead to local deformation ( strain),micro trauma, piezoelectric potentials, fluid flowing in bone canaliculus and streaming potentials. Bone’s Stress-Generated Potentials (SGP) mainly includes piezoelectric effect and electrokinetic effect. With the development of bone biomechanics, SGP research methods were improved greatly. In this article, research methods and advance of SGP in bone、bone substitute、dentin will be reviewed.