The interplay between stress and growth in solid tumors |
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| Institution: | 1. Dept. of Cardiovascular Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, Rome, Italy;2. Dept. of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, Rue des Moulins Gémeaux 36, Saint-Denis, Paris, France;3. Dept. of Cardiothoracic Surgery, Golden Jubilee National Hospital, Agamennon Street, Clydebank, Glasgow, UK;4. Dept. of Structures and Interdisciplinary Research, Center of Biomaterials, University of Naples “Federico II”, Corso Umberto I, Naples, Italy;5. Dept. of Department of Cardiothoracic Surgery, Hôpital Pitié-Salpétrière, Boulevard de l'' Hôpital 47–83, Paris, France;1. School of Mathematics, Statistics and Applied Mathematics, NUI Galway, University Road, Galway, Ireland;2. PMMH, CNRS UMR 7636, PSL, ESPCI, 10 rue de Vauquelin, Paris, 75231, France |
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| Abstract: | A number of biological phenomena are interlaced with classical mechanics. In this review we discuss the role of mechanics in tumor growth, namely the avascular phase of solid tumors. While a growing mass produces a traction of the surrounding tissues, a feedback mechanism controls the proliferation of the malignant cells depending on the tensional state. The formalism of continuum mechanics, possibly accompanied by numerical simulations, is able to shed light on biological controversial subjects. The converse is also true: non-standard mechanical problems suggest new challenging theoretical questions. |
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