| FINITE ELEMENT METHOD ON NUMERICAL SIMULATION OF STRATUM CORNEUM'S PENETRATION PROPERTY |
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| 作者姓名： | 刘宇红 乔爱科 Dirk Feuchter Gabriel Wittum 曾衍钧 |
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| 作者单位： | Biomechanics and Medical Information Institute Beijing University of Technology Beijing 100022，P. R. China，Technical Simulation Group of the Interdisciplinary Center for Scientific Computing of University Heidelberg，Im neuen Heimerfeld 368，69120，Germany，Biomechanics and Medical Information Institute Beijing University of Technology，Beijing 100022，P. R. China，Technical Simulation Group of the Interdisciplinary Center for Scientific Computing of University Heidelberg Im neuen Heimerfeld 368，69120，Germany，Technical Simulation Group of the Interdisciplinary Center for Scientific Computing of University Heidelberg Im neuen Heimerfeld 368，69120，Germany，Biomechanics and Medical Information Institute Beijing University of Technology，Beijing 100022，P. R. China |
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| 摘 要： | How the outer substance could penetrate through the skin lies in the stratum corneum, because it is the main barrier in the multi-layers of the skin. Supposing the keratin cell with a special geometry as tetrakaidecahedron, the penetration property of stratum corneum was the key problem which was numerically simulated with finite element method. At first the discretization of the stratum corneum region was given in two steps: first, the discretization of the keratin cell; second, the discretization of fattiness that surrounds the keratin. Then there was the work of numerical simulation. In this procedure, the finite element method and the multi-grid method were used. The former was to obtain the discretization of basic elements; the latter was to decrease the high frequency error. At last the visualization of the numerical simulation was shown.
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FINITE ELEMENT METHOD ON NUMERICAL SIMULATION OF STRATUM CORNEUM'S PENETRATION PROPERTY |
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| LIU Yu-hong,QIAO Ai-ke,Dirk Feuchter,Gabriel Wittum,ZENG Yan-jun.FINITE ELEMENT METHOD ON NUMERICAL SIMULATION OF STRATUM CORNEUM''''S PENETRATION PROPERTY[J].Applied Mathematics and Mechanics(English Edition),2006,27(4). |
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| Authors: | LIU Yu-hong QIAO Ai-ke Dirk Feuchter Gabriel Wittum ZENG Yan-jun |
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| Abstract: | How the outer substance could penetrate through the skin lies in the stratum corneum, because it is the main barrier in the multi-layers of the skin. Supposing the keratin cell with a special geometry as tetrakaidecahedron, the penetration property of stratum corneum was the key problem which was numerically simulated with finite element method. At first the discretization of the stratum corneum region was given in two steps: first, the discretization of the keratin cell; second, the discretization of fattiness that surrounds the keratin. Then there was the work of numerical simulation. In this procedure, the finite element method and the multi-grid method were used. The former was to obtain the discretization of basic elements; the latter was to decrease the high frequency error. At last the visualization of the numerical simulation was shown. |
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| Keywords: | stratum corneum tetrakaidecahedron discretization finite element method multi-grid method |
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