骨间膜组织间隙流场的三维数值模拟

根据解剖学发现的人体小腿骨间膜血管和胶原纤维有序排列的特点，建立三维组织间隙液渗流模型，控制方程用Brinkman方程和连续性方程，使用Fluent软件进行数值模拟. 计算结果显示，组织液在组织间隙中流动的方向总体是与平行毛细血管的方向相一致的；组织间隙多孔率会影响速度的分布，当多孔率增加时，空间的速度趋于均匀，从而使得最大速度变小，正常生理范围内多孔率的改变对于组织液流动的影响较小. 但当多孔率很小时(组织纤维化)，会大大影响组织液流动的均匀性；组织间隙平行胶原的存在，会使得组织间隙速度在空间上的分布趋于均匀；另外，间隙流场随血压的增加而增加，随组织压的增加而降低，这与临床和经络研究的发现相一致. 

ON THREE-DIMENSIONAL NUMERICAL SIMULATION OF INTERSTITIAL FLUID FLOW OF INTER OSSEOUS MEMBRANE

Interstitial fluid flow is an important component of the microcirculation and interstitial environment, yet there is few direct in vivo measurement of it within human body.Therefore,computational and mathematical models are employed to investigate the fluid flow especially within cortical bone and ligaments. This article is to investigate the interstitial fluid flow in inter osseous membrane on lower limb,where the distribution of capillaries is regular parallel arrays on certain direction which is approxim...