大分子跨血管壁的非定常扩散—模型和观察

ON THE TRANSTIENT DIFFUSION OF MACROMOLECULES THROUGH LEAKY JUNCTIONS AND THEIR SUBEN-DOTHELIAL SPREADMODEL AND OBSERVATIONS

In this two part study we shall quantitatively explose the hypothesis that fully open 20 nm intercellular clefts between widenly scattered mitotic endithelial cell are main pathway of macromolecules through endothelial. In the resent analysis, the authors heve quantitatively demonstrated that this open junction pathway could also account for the localized differences in measured macromolecular permeability in mammalian arteries in so called blue areas. In part 1 of the study we shall present a model to predict the short time labeling of the leaky junction and the local subendothelial space in the first few minutes following the introduction of the tracer molecules in order to guide experiment. In part 2 of the study, we shall present a model to describe the longer time labeling of arterial media and the transiant approch to study state behavior. We have solved the mathematical problem and obtained calculating results for different parameters.