MICRO-SCALE NUMERICAL STUDY OF THE EFFECT OF ERYTHROCYTE MECHANICAL PROPERTIES ON THE NEAR-WALL MOTION OF PLATELET |
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Authors: | Xu Jing Wang Xiaolong Liu Yunqiao Gong Xiaobo |
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Institution: | 1. Department of Engineering Mechanics, Shanghai Jiao Tong University, Shanghai 200240, China;
2. MOE Key Laboratory of Hydrodynamics, Shanghai Jiao Tong University, Shanghai 200240, China |
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Abstract: | The effect of erythrocyte mechanical properties on the near-wall motion of platelet was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by a hyper-elastic membrane with negligible thickness. The numerical results show that with the increase in hematocrit, the near-wall approaching is enhanced; platelet exhibits larger deformation and orientation (angle of its near-wall tank-treading motion); the lateral force pushing platelet to the wall is increased with larger fluctuation amplitude of lateral force, while the near-wall approaching is reduced by increasing the stiffness of erythrocytes. |
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Keywords: | hemodynamics|fluid-membrane interaction|the immersed boundary method|near-wall motion of platelet |
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