Application of solvent evaporation technique for pure drug crystal spheres preparation |
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| Institution: | 1. School of Energy and Environment Engineering, University of Science and Technology, Beijing, China;2. Beijing Engineering Research Centre of Energy Saving and Environmental Protection, China;1. Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia;2. Office of Deputy Vice Chancellor (Research and Innovation), Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor, Malaysia;3. University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1SB, England, UK;4. Centre for Sustainable Nanomaterials (CSNano), Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia;1. Institute of Nuclear and New Energy Technology, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety, Ministry of Education, Tsinghua University, Beijing 100084, China;2. School of Engineering, RMIT University, Melbourne, VIC 3083, Australia;1. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China;2. Department of Chemical and Biochemical Engineering, Western University, Ontario N6A 5B9, Canada;1. University of Connecticut, School of Pharmacy, Storrs, CT 06269, United States;2. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, United States;1. Institute of Applied Physics and Computational Mathematics, Beijing 100094, China;2. Center for Combustion Energy, Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China;3. Smoore International Holdings Ltd., Shenzhen 518102, China |
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| Abstract: | An innovative application of the solvent evaporation technique was suggested. Solvent evaporation technique is a technique for drug encapsulation and nanosphere preparation. The widely used technique is also facing the problem of low actual drug entrapment percent, which is not economic from the industrial view. The goal of this work is trying to use the advantage of this technique concerning the product sphericity and the ability to control particle size, to prepare a drug as pure crystals spheres. Ibuprofen is selected as a model drug. The spheres are formed by using Polyvinyl pyrrolidone (PVP) or Polyethylene glycol (PEG) as an anti-aggregating agent but not formed on using tween or span. Particle size and actual drug content depend on the concentrations the anti-aggregating agent used. Surfaces of the drug crystal spheres are porous with empty sphere internal structure on using PVP but spongy and rough on using PEG. The drug has its identity chemical form in the drug crystal spheres. IR scan of spheres prepared on using PEG showed a characteristic ether peak. DSC showed melting endothermic peak of PEG, but X-ray showed minor change in the drug crystal patterns. Drug release profiles from crystal spheres prepared with the same anti-aggregating agent are close to each other. The drug release profiles from drug crystal spheres prepared by using PEG are more controlled than that prepared by using PVP. The drug release mechanism is diffusion. It was concluded that, the same technique could be suggested for preparation of other biomedical material in pure crystals spheres with controlled particle size. These properties may encourage to prepare very small particles with spherical shape for inhalation or injection as an innovative particle technology application for the widely used technique. |
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| Keywords: | Solvent evaporation technique Drug crystal spheres Ibuprofen Polyvinyl pyrrolidone Polyethylene glycol |
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