NMR Studies of Drugs. Applications of Achiral and Chiral Wthanide Shift Reagents to Bupropion |
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| Authors: | Ronnie Benshafrut Robert Rothchild Mark E Sullivan Kunisi S Venkatasubban |
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| Institution: | 1. The City University of New York, John Jay College of Criminal Justice, Department of Science, Toxicology Research and Training Center , 445 West 59th Street, New York, NY, 10019-1199;2. University of North Florida, Department of Natural Sciences , P.O. Box 17074, Jacksonville , FL, 32216 |
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| Abstract: | Abstract The 1H NMR spectra of racemic samples of the antidepressant drug, bupropion, 1, have been studied in CDCl3 solution at 60 and 200 MHz with the achiral lanthanide shift reagent (LSR), tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)europium (III), 2, and the chiral reagent, tris3-(heptafluoropropylhydroxymethylene)-d-camphorato]europium(III), 3. Both LSR produced substantial lanthanide induced shifts consistent with 1H assignments, but the bound complexes of 1 with 2 versus 3 may not be isostructural. With 3, substantial enantiomeric shift differences were observed for the t-butyl, CH 3CH, NCH, and the aryl H-2 and H-6 signals, which should permit potential direct determination of enantiomeric excess. |
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| Keywords: | NMR Shift Reagents Enantiomer Optical Purity Eu(FOD)3 Eu(HFC)3 Chiral Bupropion Analysis 1-(3-Chlorophenyl)-2-[(1 1-dimethylethyl)amino]-1-propanone |
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