耐腐蚀聚合药物基体上药物的扩散释放

主要对耐腐蚀聚合药物基体上药物的整个释放过程进行解析和数值研究.数学模型为基于Fick第二法则的边值问题,分为状态Ⅰ和Ⅱ.状态Ⅰ为具有移动性扩散波头的Stefan问题,而当此扩散波头消失时,即开始状态Ⅱ.该研究工作可作为数值研究更加复杂系统的基础之一.

Analytic Solution of the Diffusional Release of Solute from a Non-erodible Polymeric Matrix

This work presents a systematic framework to achieve the desired diffusional release of drug from a non-erodible poly-meric matrix. The model of this representation is a boundary value problem based on Fick' s second law. The solution of this govern-ing equation is divided into two phases. Phase Ⅰ is a Stefan problem with a moving diffusion front while Phase Ⅱ begins after themoving diffusion front has disappeared. The main objective of the present study is to investigate analytically the complete releaseprocess of a solute from a non-erodible matrix up to a time corresponding to the absence of the diffusion front. This solution mayserve as a basis for modeling more complicated systems.