Photoacoustic study of percutaneous absorption of Carbopol and
transdermic gels for topic use in skin |
| |
Authors: | R CP Rossi R F de Paiva M D da Silva P R Barja |
| |
Institution: | 1.Instituto de Pesquisa & Desenvolvimento (IP&D), Universidade do Vale do Paraíba (UNIVAP),SP,Brazil;2.Laboratório Associado de Sensores e Materiais (LAS), Instituto Nacional de Pesquisas Espaciais (INPE),SP,Brazil |
| |
Abstract: | Topical medicine application has been used to treat a
good number of pathological processes. Its efficacy is associated to an
efficient penetration of the drug in the internal skin layers, promoting
systemic effects and excluding the possibility of drug degradation by the
digestive tract and hepatic elimination. This work analyzes the penetration
kinetics of two soluble bases employed as vehicles for topic application:
superficial gel (Carbopol 940) and transdermic (transdermal) gel. Analysis
was performed with the photoacoustic technique, based upon the absorption of
modulated light by a sample with subsequent conversion of the absorbed
energy in heat, generating acoustic waves in the air layer adjacent to the
sample. Each of the two vehicles was evaluated through in vivo (human skin) and in vitro
application. Measurements in vitro employed samples of VitroSkin (synthetic material
with properties similar to those of real skin, employed in the
pharmaceutical industry research). Results show that the permeation was
faster for the transdermal gel, both for in vivo and in vitro measurements, indicating that
in vitro measurements may be utilized in qualitative, comparative permeation
studies. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|