A calibration technique for frequency domain photothermoacoustics |
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| Authors: | G M Spirou A Mandelis I A Vitkin W M Whelan |
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| Institution: | (1) Department of Medical Physics, McMaster University, Hamilton, Ontario, Canada;(2) Center of Advanced Diffusion-Wave Technologies, Departments of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada;(3) Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;(4) Division of Biophysics and Bioimaging, University of Toronto, Ontario Cancer Institute/Princess Margaret Hospital/University Health Network, Toronto, Ontario, Canada;(5) Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada;(6) Department of Physics, Ryerson University, Toronto, Ontario, Canada |
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| Abstract: | Photoacoustic (or more precisely, photothermoacoustic)
signals are generated by the absorption of photons, expressed as acoustic
waves, and can be related to the incident laser fluence rate. Here a
calibration procedure for frequency domain (FD) photoacoustics is presented
which utilizes the relationship between photoacoustic (PA) signal amplitude
and laser fluence rate. The sample is irradiated with a continuous wave
laser which is amplitude modulated at varying frequencies. Applying the
calibration procedure to the PA detected signals, a linear relationship is
obtained between the fluence rate and the signal amplitude. |
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