首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Oscillatory expression and variability in p53 regulatory network
Authors:Bo LiuShiwei Yan  Qi WangShengjun Liu
Institution:
  • a College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China
  • b Beijing Radiation Center, Beijing 100875, China
  • c Center of Theoretical Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China
  • Abstract:The effect of delay, nonlinearity and noise on oscillatory motion is of permanent interest for theoretical and experimental research. Here we explore a negative feedback loop between p53 and Mdm2 with a time delay, which is a key circuit in the response of cells to damage. This circuit shows noisy sustained oscillations in individual human cells following DNA damage, and damped oscillations at the cell population level. We demonstrate the effect of delay on the oscillation, and the correlation in time course. In a multi-species system, the events at different time points which span a time delay are coupled even when the delay is large compared with the other characteristic times of the system. We also clarify that the dynamics at the single-cell level appears to be coherent resonance, and the origin of the damped oscillation at the macroscopic level out of the sustained ones at the single-cell level can be ascribed to the dephasing process which is induced by the interplay between nonlinearity and noise. The findings are consistent with experimental observations and advance our understanding of the dynamics of the p53 network.
    Keywords:Cancer genetics  Master equation  Nonlinear feedback  p53-Mdm2 system
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号