Transport by Molecular Motors in the Presence of Static Defects |
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Authors: | Yan Chai Reinhard Lipowsky and Stefan Klumpp |
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Institution: | (1) Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany;(2) Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, CA 92093-0374, USA |
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Abstract: | The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects.
The movements of single motors are described as biased random walks along the filament as well as binding to and unbinding
from the filament. Three basic types of defects are distinguished, which differ from normal filament sites only in one of
the motors’ transition probabilities. Both stepping defects with a reduced probability for forward steps and unbinding defects
with an increased probability for motor unbinding strongly reduce the velocities and the run lengths of the motors with increasing
defect density. For transport by single motors, binding defects with a reduced probability for motor binding have a relatively
small effect on the transport properties. For cargo transport by motors teams, binding defects also change the effective unbinding
rate of the cargo particles and are expected to have a stronger effect. |
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Keywords: | Molecular motors Defective filaments Motor walks Motor traffic Run length Lattice models |
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