The Influence of T Cell Development on Pathogen Specificity and Autoreactivity |
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Authors: | Andrej Ko?mrlj Mehran Kardar Arup K Chakraborty |
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Institution: | 1. Department of Physics, Harvard University, Cambridge, MA, 02138, USA 2. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA 3. Departments of Chemical Engineering, Chemistry, Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA 4. Ragon Institute of MGH, MIT, & Harvard, Boston, MA, 02129, USA
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Abstract: | T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells. T?cells can also interact with peptide-MHC complexes, where the peptide is derived from host (self) proteins. A diverse repertoire of relatively self-tolerant T cell receptors is selected in the thymus. We study a model, computationally and analytically, to describe how thymic selection shapes the repertoire of T cell receptors, such that T cell receptor recognition of pathogenic peptides is both specific and degenerate. We also discuss the escape probability of autoimmune T cells from the thymus. |
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